Inactivation of staphylococcal phenol soluble modulins by serum lipoprotein particles

Staphylococcus aureus virulence has been associated with the production of phenol soluble modulins (PSM). PSM are known to activate, attract and lyse neutrophils. However, the functional characterizations were generally performed in the absence of human serum. Here, we demonstrate that human serum c...

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Veröffentlicht in:	PLoS pathogens 2012-03, Vol.8 (3), p.e1002606
Hauptverfasser:	Surewaard, Bas G J, Nijland, Reindert, Spaan, András N, Kruijtzer, John A W, de Haas, Carla J C, van Strijp, Jos A G
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial Proteins - immunology Bacterial Proteins - metabolism Bacterial Proteins - toxicity Bacterial Toxins - immunology Bacterial Toxins - metabolism Bacterial Toxins - toxicity Bacteriology Biology Blood lipoproteins Calcium - metabolism Calcium Signaling Health aspects HL-60 Cells - immunology HL-60 Cells - metabolism Humans Immune system Lipoproteins Lipoproteins - blood Microbiology Neutralization Tests Neutrophils - drug effects Neutrophils - metabolism Phenol - chemistry Phenols Physiological aspects Protein Binding Proteins Proteolipids Solubility Staphylococcus aureus Staphylococcus aureus - immunology Staphylococcus aureus - metabolism Staphylococcus aureus - pathogenicity Staphylococcus infections Virulence (Microbiology) Virulence Factors - immunology Virulence Factors - metabolism Virulence Factors - toxicity
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