Nasal Acai polysaccharides potentiate innate immunity to protect against pulmonary Francisella tularensis and Burkholderia pseudomallei Infections

Pulmonary Francisella tularensis and Burkholderia pseudomallei infections are highly lethal in untreated patients, and current antibiotic regimens are not always effective. Activating the innate immune system provides an alternative means of treating infection and can also complement antibiotic ther...

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Veröffentlicht in:	PLoS pathogens 2012-03, Vol.8 (3), p.e1002587
Hauptverfasser:	Skyberg, Jerod A, Rollins, MaryClare F, Holderness, Jeff S, Marlenee, Nicole L, Schepetkin, Igor A, Goodyear, Andrew, Dow, Steven W, Jutila, Mark A, Pascual, David W
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intranasal Aerosols Animals Antibiotics Arecaceae - chemistry Berries Biological & chemical terrorism Biology Burkholderia pseudomallei Burkholderia pseudomallei - drug effects Burkholderia pseudomallei - immunology Cell culture Colleges & universities Cytotoxicity Disease Models, Animal Experiments Female Francisella tularensis Francisella tularensis - drug effects Francisella tularensis - immunology Health aspects Immune system Immunity, Innate - drug effects Immunology Infections Interferon-gamma - metabolism Killer Cells, Natural - drug effects Killer Cells, Natural - immunology Killer Cells, Natural - metabolism Longevity - drug effects Lung - drug effects Lung - immunology Lung - metabolism Macrophages - drug effects Macrophages - immunology Macrophages - metabolism Melioidosis - immunology Melioidosis - prevention & control Mice Mice, Inbred BALB C Mice, Inbred C57BL Mortality Neutralization Physiological aspects Plant Extracts - administration & dosage Plant Extracts - pharmacology Pneumonia - drug therapy Pneumonia - immunology Pneumonia - microbiology Polysaccharides Polysaccharides - administration & dosage Polysaccharides - isolation & purification Polysaccharides - pharmacology Saccharides Survival Tularemia Tularemia - immunology Tularemia - prevention & control Virulence (Microbiology)
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