Recurrent signature patterns in HIV-1 B clade envelope glycoproteins associated with either early or chronic infections

Here we have identified HIV-1 B clade Envelope (Env) amino acid signatures from early in infection that may be favored at transmission, as well as patterns of recurrent mutation in chronic infection that may reflect common pathways of immune evasion. To accomplish this, we compared thousands of sequ...

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Veröffentlicht in:	PLoS pathogens 2011-09, Vol.7 (9), p.e1002209
Hauptverfasser:	Gnanakaran, S, Bhattacharya, Tanmoy, Daniels, Marcus, Keele, Brandon F, Hraber, Peter T, Lapedes, Alan S, Shen, Tongye, Gaschen, Brian, Krishnamoorthy, Mohan, Li, Hui, Decker, Julie M, Salazar-Gonzalez, Jesus F, Wang, Shuyi, Jiang, Chunlai, Gao, Feng, Swanstrom, Ronald, Anderson, Jeffrey A, Ping, Li-Hua, Cohen, Myron S, Markowitz, Martin, Goepfert, Paul A, Saag, Michael S, Eron, Joseph J, Hicks, Charles B, Blattner, William A, Tomaras, Georgia D, Asmal, Mohammed, Letvin, Norman L, Gilbert, Peter B, Decamp, Allan C, Magaret, Craig A, Schief, William R, Ban, Yih-En Andrew, Zhang, Ming, Soderberg, Kelly A, Sodroski, Joseph G, Haynes, Barton F, Shaw, George M, Hahn, Beatrice H, Korber, Bette
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome Adaptive Immunity AIDS AIDS vaccines amino acid analysis Amino Acid Motifs Amino Acid Substitution Amino acids antibodies Antibodies, Viral - immunology BASIC BIOLOGICAL SCIENCES Binding sites (Biochemistry) Binding Sites - genetics Biology CD4 Antigens - genetics CD4 Antigens - immunology Chronic Disease env Gene Products, Human Immunodeficiency Virus - biosynthesis env Gene Products, Human Immunodeficiency Virus - genetics Gene Expression Regulation, Viral - physiology Genetic aspects Glycosylation Health aspects HIV HIV infection HIV Infections - genetics HIV Infections - immunology HIV-1 HIV-1 - genetics HIV-1 - immunology HIV-1 - pathogenicity Human immunodeficiency virus Immune response Infections Medicine multiple alignment calculation Mutation Mutation, Missense phylogenetic analysis Physiological aspects Prevention protein sequencing Protein Sorting Signals - genetics Receptors, CCR5 - genetics Receptors, CCR5 - immunology Retrospective Studies Risk factors sequence alignment
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