Clonal structure of rapid-onset MDV-driven CD4+ lymphomas and responding CD8+ T cells

Lymphoid oncogenesis is a life threatening complication associated with a number of persistent viral infections (e.g. EBV and HTLV-1 in humans). With many of these infections it is difficult to study their natural history and the dynamics of tumor formation. Marek's Disease Virus (MDV) is a pre...

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Veröffentlicht in:	PLoS pathogens 2011-05, Vol.7 (5), p.e1001337-e1001337
Hauptverfasser:	Mwangi, William N, Smith, Lorraine P, Baigent, Susan J, Beal, Richard K, Nair, Venugopal, Smith, Adrian L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Base Sequence Care and treatment Causes of CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Cell Line, Tumor Chickens Complementarity Determining Regions E coli Experiments Genetic aspects Genomes Health aspects Herpesvirus 2, Gallid - immunology Herpesvirus 2, Gallid - pathogenicity Immune System Immunology/Cellular Microbiology and Pathogenesis Immunology/Immunity to Infections Infections Infectious Diseases/Viral Infections Lymphocyte Activation Lymphocyte Count Lymphocytes Lymphoma Lymphoma - pathology Lymphoma - virology Marek Disease - immunology Marek Disease - virology Marek's disease Molecular Sequence Data Oncology/Myelomas and Lymphoproliferative Diseases Pathology/Immunology Physiology/Immunity to Infections Prevention Receptors, Antigen, T-Cell, alpha-beta - genetics Receptors, Antigen, T-Cell, alpha-beta - immunology Spleen T cells Tumors Viral infections Virology/Animal Models of Infection Virology/Host Antiviral Responses Virology/Viruses and Cancer
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