Concerted actions of a thermo-labile regulator and a unique intergenic RNA thermosensor control Yersinia virulence

Expression of all Yersinia pathogenicity factors encoded on the virulence plasmid, including the yop effector and the ysc type III secretion genes, is controlled by the transcriptional activator LcrF in response to temperature. Here, we show that a protein- and RNA-dependent hierarchy of thermosenso...

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Veröffentlicht in:	PLoS pathogens 2012-02, Vol.8 (2), p.e1002518-e1002518
Hauptverfasser:	Böhme, Katja, Steinmann, Rebekka, Kortmann, Jens, Seekircher, Stephanie, Heroven, Ann Kathrin, Berger, Evelin, Pisano, Fabio, Thiermann, Tanja, Wolf-Watz, Hans, Narberhaus, Franz, Dersch, Petra
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacterial Proteins - genetics Base Sequence Binding sites Biology Blotting, Northern Blotting, Western Female Gene Expression Regulation, Bacterial - genetics Gene Knockout Techniques Genes Genes, Bacterial Genetic aspects Genetic engineering Genetic transcription Health aspects Mice Mice, Inbred BALB C Microbiology Molecular Sequence Data Molecular weight Mortality Physiological aspects Polymerase Chain Reaction Proteins RNA RNA, Bacterial - genetics Signal transduction Temperature Trans-Activators - genetics Viral genetics Virulence (Microbiology) Virulence - genetics Virulence Factors - genetics Yersinia Yersinia - genetics Yersinia - pathogenicity Yersinia Infections - genetics
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