Early secreted antigen ESAT-6 of Mycobacterium tuberculosis promotes protective T helper 17 cell responses in a toll-like receptor-2-dependent manner

Despite its relatively poor efficacy, Bacillus Calmette-Guérin (BCG) has been used as a tuberculosis (TB) vaccine since its development in 1921. BCG induces robust T helper 1 (Th1) immune responses but, for many individuals, this is not sufficient for host resistance against Mycobacterium tuberculos...

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Veröffentlicht in:	PLoS pathogens 2011-11, Vol.7 (11), p.e1002378-e1002378
Hauptverfasser:	Chatterjee, Samit, Dwivedi, Ved Prakash, Singh, Yogesh, Siddiqui, Imran, Sharma, Pawan, Van Kaer, Luc, Chattopadhyay, Debprasad, Das, Gobardhan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Bacterial - immunology Antigens, Bacterial - metabolism Bacterial Proteins - immunology Bacterial Proteins - metabolism BCG Vaccine - immunology Biology Dendritic Cells - immunology Dendritic Cells - metabolism Health aspects Immune response Immune system Immunology Infections Interleukin-6 - biosynthesis Lung - immunology Lung - microbiology Medicine Mice Mice, Inbred C57BL Mice, Knockout Mycobacterium bovis - immunology Mycobacterium bovis - pathogenicity Mycobacterium tuberculosis Mycobacterium tuberculosis - immunology Mycobacterium tuberculosis - metabolism Mycobacterium tuberculosis - pathogenicity Myeloid Differentiation Factor 88 - metabolism Physiological aspects Proteins T cell receptors T cells Th1 Cells - immunology Th17 Cells - immunology Toll-Like Receptor 2 - genetics Toll-Like Receptor 2 - immunology Toll-Like Receptor 2 - metabolism Toll-like receptors Transforming Growth Factor beta - biosynthesis Tuberculosis Tuberculosis - immunology Tuberculosis - prevention & control Vaccines
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