Whole genome deep sequencing of HIV-1 reveals the impact of early minor variants upon immune recognition during acute infection

Deep sequencing technologies have the potential to transform the study of highly variable viral pathogens by providing a rapid and cost-effective approach to sensitively characterize rapidly evolving viral quasispecies. Here, we report on a high-throughput whole HIV-1 genome deep sequencing platform...

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Veröffentlicht in:	PLoS pathogens 2012-03, Vol.8 (3), p.e1002529-e1002529
Hauptverfasser:	Henn, Matthew R, Boutwell, Christian L, Charlebois, Patrick, Lennon, Niall J, Power, Karen A, Macalalad, Alexander R, Berlin, Aaron M, Malboeuf, Christine M, Ryan, Elizabeth M, Gnerre, Sante, Zody, Michael C, Erlich, Rachel L, Green, Lisa M, Berical, Andrew, Wang, Yaoyu, Casali, Monica, Streeck, Hendrik, Bloom, Allyson K, Dudek, Tim, Tully, Damien, Newman, Ruchi, Axten, Karen L, Gladden, Adrianne D, Battis, Laura, Kemper, Michael, Zeng, Qiandong, Shea, Terrance P, Gujja, Sharvari, Zedlack, Carmen, Gasser, Olivier, Brander, Christian, Hess, Christoph, Günthard, Huldrych F, Brumme, Zabrina L, Brumme, Chanson J, Bazner, Suzane, Rychert, Jenna, Tinsley, Jake P, Mayer, Ken H, Rosenberg, Eric, Pereyra, Florencia, Levin, Joshua Z, Young, Sarah K, Jessen, Heiko, Altfeld, Marcus, Birren, Bruce W, Walker, Bruce D, Allen, Todd M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptations Algorithms Biology CD8 antigen CD8-Positive T-Lymphocytes - immunology Data processing DNA sequencing Epitopes Evolution Genetic aspects Genetic Variation Genome, Viral - genetics Genome-Wide Association Study Genomes Genomic Structural Variation Genomics Health aspects Histocompatibility antigen HLA HIV (Viruses) HIV Infections - immunology HIV Infections - prevention & control HIV Infections - virology HIV-1 - genetics HIV-1 - immunology HIV-1 - pathogenicity Human immunodeficiency virus 1 Humans Immune Evasion - genetics Immune Evasion - immunology Immune response Immune system Immunity Immunology Infection Infections Lymphocytes T Medicine Mutation Nucleotide sequencing Oligonucleotide Array Sequence Analysis Pathogens Physiological aspects Replication Reversion RNA, Viral - analysis Sequence Analysis, RNA Vaccines Viral genetics Viral Vaccines - immunology Viremia
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