Leprosy and the adaptation of human toll-like receptor 1

Leprosy is an infectious disease caused by the obligate intracellular pathogen Mycobacterium leprae and remains endemic in many parts of the world. Despite several major studies on susceptibility to leprosy, few genomic loci have been replicated independently. We have conducted an association analys...

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Veröffentlicht in:	PLoS pathogens 2010-07, Vol.6 (7), p.e1000979-e1000979
Hauptverfasser:	Wong, Sunny H, Gochhait, Sailesh, Malhotra, Dheeraj, Pettersson, Fredrik H, Teo, Yik Y, Khor, Chiea C, Rautanen, Anna, Chapman, Stephen J, Mills, Tara C, Srivastava, Amit, Rudko, Aleksey, Freidin, Maxim B, Puzyrev, Valery P, Ali, Shafat, Aggarwal, Shweta, Chopra, Rupali, Reddy, Belum S N, Garg, Vijay K, Roy, Suchismita, Meisner, Sarah, Hazra, Sunil K, Saha, Bibhuti, Floyd, Sian, Keating, Brendan J, Kim, Cecilia, Fairfax, Benjamin P, Knight, Julian C, Hill, Philip C, Adegbola, Richard A, Hakonarson, Hakon, Fine, Paul E M, Pitchappan, Ramasamy M, Bamezai, Rameshwar N K, Hill, Adrian V S, Vannberg, Fredrik O
Format:	Artikel
Sprache:	eng
Schlagworte:	Care and treatment Demographic aspects Diagnosis Disease Gene Frequency Gene loci Genetic Predisposition to Disease - genetics Genetic susceptibility Genetic variation Genetics Genetics and Genomics/Bioinformatics Genetics and Genomics/Complex Traits Genetics and Genomics/Genetics of Disease Genetics and Genomics/Genetics of the Immune System Genetics and Genomics/Medical Genetics Genetics and Genomics/Microbial Evolution and Genomics Genetics and Genomics/Population Genetics Genome-Wide Association Study Genomes HLA-DQ alpha-Chains HLA-DQ Antigens - genetics HLA-DR Antigens - genetics HLA-DRB1 Chains Humans Identification and classification Infectious Diseases/Bacterial Infections Infectious Diseases/Skin Infections Leprosy Leprosy - genetics Leprosy - immunology Mycobacterium leprae Mycobacterium leprae - immunology Pathogenesis Population Principal components analysis Public Health and Epidemiology/Epidemiology Public Health and Epidemiology/Infectious Diseases Studies Toll-Like Receptor 1 - genetics Toll-Like Receptor 1 - immunology Tuberculosis
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