Plus- and minus-end directed microtubule motors bind simultaneously to herpes simplex virus capsids using different inner tegument structures

Many viruses depend on host microtubule motors to reach their destined intracellular location. Viral particles of neurotropic alphaherpesviruses such as herpes simplex virus 1 (HSV1) show bidirectional transport towards the cell center as well as the periphery, indicating that they utilize microtubu...

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Veröffentlicht in:	PLoS pathogens 2010-07, Vol.6 (7), p.e1000991-e1000991
Hauptverfasser:	Radtke, Kerstin, Kieneke, Daniela, Wolfstein, André, Michael, Kathrin, Steffen, Walter, Scholz, Tim, Karger, Axel, Sodeik, Beate
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites Biochemistry/Biomacromolecule-Ligand Interactions Biochemistry/Cell Signaling and Trafficking Structures Biochemistry/Macromolecular Assemblies and Machines Biomedical research Brain Brain research Capsid - metabolism Capsid Proteins - metabolism Cell Biology/Cytoskeleton Cell Biology/Neuronal and Glial Cell Biology Cell-Free System Dynactin Complex Dynein Dyneins - metabolism Experiments Genetic aspects Herpes simplex virus Herpes simplex virus 1 Humans Hypotheses Kinesin - metabolism Microscopy Microtubule-Associated Proteins - metabolism Microtubules Microtubules - metabolism Molecular Motor Proteins - metabolism Molecular weight Properties Protein Transport Proteins Simplexvirus - ultrastructure Structure Virology/Host Invasion and Cell Entry Virology/Virion Structure, Assembly, and Egress Viruses
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