A capsid-encoded PPxY-motif facilitates adenovirus entry

Viruses use cellular machinery to enter and infect cells. In this study we address the cell entry mechanisms of nonenveloped adenoviruses (Ads). We show that protein VI, an internal capsid protein, is rapidly exposed after cell surface attachment and internalization and remains partially associated...

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Veröffentlicht in:	PLoS pathogens 2010-03, Vol.6 (3), p.e1000808-e1000808
Hauptverfasser:	Wodrich, Harald, Henaff, Daniel, Jammart, Baptist, Segura-Morales, Carolina, Seelmeir, Sigrid, Coux, Olivier, Ruzsics, Zsolt, Wiethoff, Christopher M, Kremer, Eric J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenovirus Infections, Human Adenovirus Infections, Human - virology Adenoviruses Adenoviruses, Human Adenoviruses, Human - genetics Adenoviruses, Human - growth & development Capsid Proteins Capsid Proteins - chemistry Capsid Proteins - genetics Capsid Proteins - metabolism Cell Line, Tumor Colleges & universities Conserved Sequence Endosomal Sorting Complexes Required for Transport Endosomal Sorting Complexes Required for Transport - metabolism Endosomes Endosomes - metabolism Endosomes - virology Epithelial Cells Epithelial Cells - cytology Epithelial Cells - virology Genetic aspects Humans Life Sciences Lung Lung - cytology Microbiology and Parasitology Microtubule-Organizing Center Microtubule-Organizing Center - metabolism Microtubule-Organizing Center - virology Microtubules Microtubules - metabolism Microtubules - virology Motion pictures Nedd4 Ubiquitin Protein Ligases Osteosarcoma Physiological aspects Protein Structure, Tertiary Proteins Recruitment Retinal Pigment Epithelium Retinal Pigment Epithelium - cytology Ubiquitin-Protein Ligases Ubiquitin-Protein Ligases - metabolism Ubiquitination Ubiquitination - physiology Viral envelopes Virology/Host Invasion and Cell Entry Virology/Virion Structure, Assembly, and Egress Viruses
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