Helicobacter pylori lipopolysaccharide is synthesized via a novel pathway with an evolutionary connection to protein N-glycosylation

Lipopolysaccharide (LPS) is a major component on the surface of Gram negative bacteria and is composed of lipid A-core and the O antigen polysaccharide. O polysaccharides of the gastric pathogen Helicobacter pylori contain Lewis antigens, mimicking glycan structures produced by human cells. The inte...

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Veröffentlicht in:	PLoS pathogens 2010-03, Vol.6 (3), p.e1000819-e1000819
Hauptverfasser:	Hug, Isabelle, Couturier, Marc R, Rooker, Michelle M, Taylor, Diane E, Stein, Markus, Feldman, Mario F
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteriology Biochemistry/Macromolecular Assemblies and Machines Biosynthesis Cell Line Epithelial Cells - metabolism Epithelial Cells - microbiology Escherichia coli - enzymology Escherichia coli - genetics Escherichia coli Proteins - genetics Escherichia coli Proteins - metabolism Evolution, Molecular Gastric Mucosa - cytology Gastroenterology and Hepatology/Gastrointestinal Infections Genetic aspects Glycosylation Glycosyltransferases - genetics Glycosyltransferases - metabolism Helicobacter pylori Helicobacter pylori - enzymology Helicobacter pylori - genetics Humans Infections Infectious Diseases/Bacterial Infections Infectious Diseases/Gastrointestinal Infections Lewis Blood-Group System - metabolism Ligases - genetics Ligases - metabolism Lipopolysaccharides Lipopolysaccharides - biosynthesis Microbiology Microbiology/Cellular Microbiology and Pathogenesis Mutation O Antigens - genetics O Antigens - metabolism Peptidyl Transferases - metabolism Phenotype Phosphotransferases (Alcohol Group Acceptor) - genetics Phosphotransferases (Alcohol Group Acceptor) - metabolism Physiological aspects Proteins Transferases (Other Substituted Phosphate Groups) - genetics Transferases (Other Substituted Phosphate Groups) - metabolism Ulcers
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