The killing of African trypanosomes by ethidium bromide

Introduced in the 1950s, ethidium bromide (EB) is still used as an anti-trypanosomal drug for African cattle although its mechanism of killing has been unclear and controversial. EB has long been known to cause loss of the mitochondrial genome, named kinetoplast DNA (kDNA), a giant network of interl...

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Veröffentlicht in:	PLoS pathogens 2010-12, Vol.6 (12), p.e1001226
Hauptverfasser:	Roy Chowdhury, Arnab, Bakshi, Rahul, Wang, Jianyang, Yildirir, Gokben, Liu, Beiyu, Pappas-Brown, Valeria, Tolun, Gökhan, Griffith, Jack D, Shapiro, Theresa A, Jensen, Robert E, Englund, Paul T
Format:	Artikel
Sprache:	eng
Schlagworte:	African trypanosomiasis Antiprotozoal Agents - pharmacology Biochemistry/Drug Discovery Bromides Bubbles Care and treatment Cattle Chemotherapy Deoxyribonucleic acid DNA DNA replication DNA Replication - drug effects DNA, Kinetoplast - drug effects DNA, Z-Form Dosage and administration Editing Enzymes Ethidium - pharmacology Genome, Mitochondrial - drug effects Genomes Infectious Diseases/Neglected Tropical Diseases Infectious Diseases/Protozoal Infections Microbiology/Parasitology Molecular Biology/DNA Nucleic Acid Conformation Parasites Pharmacology Proteins Studies Trypanosoma - drug effects Trypanosoma brucei brucei Trypanosomiasis, African
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