B cell activation by outer membrane vesicles--a novel virulence mechanism

Secretion of outer membrane vesicles (OMV) is an intriguing phenomenon of Gram-negative bacteria and has been suggested to play a role as virulence factors. The respiratory pathogens Moraxella catarrhalis reside in tonsils adjacent to B cells, and we have previously shown that M. catarrhalis induce...

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Veröffentlicht in:	PLoS pathogens 2010-01, Vol.6 (1), p.e1000724-e1000724
Hauptverfasser:	Vidakovics, Maria Laura A Perez, Jendholm, Johan, Mörgelin, Matthias, Månsson, Anne, Larsson, Christer, Cardell, Lars-Olaf, Riesbeck, Kristian
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesins, Bacterial - immunology Amino acids B cells B-Lymphocytes - immunology B-Lymphocytes - metabolism Bacteria Basic Medicine Blotting, Western Branhamella catarrhalis Cell Membrane - immunology Cell Membrane - metabolism Cell Separation Child Child, Preschool Chronic obstructive pulmonary disease CpG Islands - immunology Ear diseases Electrophoresis, Polyacrylamide Gel Enzyme-Linked Immunosorbent Assay Experiments Flow Cytometry Gas vesicles Gram-negative bacteria Health aspects Humans Immune system Immunoglobulin D - immunology Immunology Immunology/Innate Immunity Infectious Diseases/Bacterial Infections Lymphocyte Activation - immunology Medical and Health Sciences Medicin och hälsovetenskap Medicinska och farmaceutiska grundvetenskaper Membrane Microdomains - immunology Membrane Microdomains - metabolism Microbiology Microbiology in the medical area Microbiology/Innate Immunity Microbiology/Medical Microbiology Microscopy, Confocal Microscopy, Electron, Transmission Microscopy, Fluorescence Mikrobiologi inom det medicinska området Moraxella (Branhamella) catarrhalis - immunology Moraxella (Branhamella) catarrhalis - pathogenicity Moraxella catarrhalis Moraxellaceae Infections - immunology Palatine Tonsil - immunology Physiological aspects Proteins R&D Receptors, Antigen, B-Cell - immunology Research & development Reverse Transcriptase Polymerase Chain Reaction Signal Transduction - immunology Sinusitis - immunology Sinusitis - microbiology Statistical analysis T cell receptors Virulence Virulence (Microbiology)
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