Rescue of inhibitory synapse strength following developmental hearing loss

Inhibitory synapse dysfunction may contribute to many developmental brain disorders, including the secondary consequences of sensory deprivation. In fact, developmental hearing loss leads to a profound reduction in the strength of inhibitory postsynaptic currents (IPSCs) in the auditory cortex, and...

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Veröffentlicht in:	PloS one 2013-01, Vol.8 (1), p.e53438-e53438
Hauptverfasser:	Kotak, Vibhakar C, Takesian, Anne E, MacKenzie, Patricia C, Sanes, Dan H
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Adults Animals Auditory defects Baclofen Baclofen - pharmacology Baclofen - therapeutic use Biology Brain Brain research Brain slice preparation Cochlea - drug effects Cochlea - physiopathology Cortex (auditory) Cortex (somatosensory) Developmental disabilities Disorders GABA GABA Uptake Inhibitors - pharmacology GABA Uptake Inhibitors - therapeutic use GABA-A Receptor Agonists - pharmacology GABA-A Receptor Agonists - therapeutic use Gerbillinae - physiology Hearing loss Hearing Loss - drug therapy Hearing Loss - pathology Hearing Loss - physiopathology Inhibitory postsynaptic potentials Inhibitory Postsynaptic Potentials - drug effects Laboratory animals Maturation Medicine Neural Inhibition - drug effects Neurodevelopmental disorders Neurons Pyramidal cells Pyridines - pharmacology Pyridines - therapeutic use Receptor mechanisms Receptors, GABA-A - metabolism Restoration Rodents Sensory deprivation Strength Synapses - drug effects Synapses - pathology Thalamus Veterinary Science Zolpidem γ-Aminobutyric acid A receptors γ-Aminobutyric acid B receptors
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