Characterizing sympathetic neurovascular transduction in humans
Despite its critical role for cardiovascular homeostasis in humans, only a few studies have directly probed the transduction of sympathetic nerve activity to regional vascular responses--sympathetic neurovascular transduction. Those that have variably relied on either vascular resistance or vascular...
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| description | Despite its critical role for cardiovascular homeostasis in humans, only a few studies have directly probed the transduction of sympathetic nerve activity to regional vascular responses--sympathetic neurovascular transduction. Those that have variably relied on either vascular resistance or vascular conductance to quantify the responses. However, it remains unclear which approach would better reflect the physiology. We assessed the utility of both of these as well as an alternative approach in 21 healthy men. We recorded arterial pressure (Finapres), peroneal sympathetic nerve activity (microneurography), and popliteal blood flow (Doppler) during isometric handgrip exercise to fatigue. We quantified and compared transduction via the relation of sympathetic activity to resistance and to conductance and via an adaptation of Poiseuille's relation including pressure, sympathetic activity, and flow. The average relationship between sympathetic activity and resistance (or conductance) was good when assessed over 30-second averages (mean R(2) = 0.49±0.07) but lesser when incorporating beat-by-beat time lags (R(2) = 0.37±0.06). However, in a third of the subjects, these relations provided relatively weak estimates (R(2)0.50 in 20 of 21 individuals), and provided reproducible estimates of transduction. The gain derived from the relation of resistance (but not conductance) was inversely related to transduction (R(2) = 0.37, p |
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Those that have variably relied on either vascular resistance or vascular conductance to quantify the responses. However, it remains unclear which approach would better reflect the physiology. We assessed the utility of both of these as well as an alternative approach in 21 healthy men. We recorded arterial pressure (Finapres), peroneal sympathetic nerve activity (microneurography), and popliteal blood flow (Doppler) during isometric handgrip exercise to fatigue. We quantified and compared transduction via the relation of sympathetic activity to resistance and to conductance and via an adaptation of Poiseuille's relation including pressure, sympathetic activity, and flow. The average relationship between sympathetic activity and resistance (or conductance) was good when assessed over 30-second averages (mean R(2) = 0.49±0.07) but lesser when incorporating beat-by-beat time lags (R(2) = 0.37±0.06). However, in a third of the subjects, these relations provided relatively weak estimates (R(2)<0.33). In contrast, the Poiseuille relation reflected vascular responses more accurately (R(2) = 0.77±0.03, >0.50 in 20 of 21 individuals), and provided reproducible estimates of transduction. The gain derived from the relation of resistance (but not conductance) was inversely related to transduction (R(2) = 0.37, p<0.05), but with a proportional bias. Thus, vascular resistance and conductance may not always be reliable surrogates for regional sympathetic neurovascular transduction, and assessment from a Poiseuille relation between pressure, sympathetic nerve activity, and flow may provide a better foundation to further explore differences in transduction in humans.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0053769</identifier><identifier>PMID: 23326501</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Arterial Pressure - physiology ; Biology ; Blood flow ; Blood pressure ; Circulatory system ; Conductance ; Exercise - physiology ; Fatigue ; Hand Strength - physiology ; Hemodynamics ; Homeostasis ; Humans ; Isometric ; Leg - blood supply ; Leg - physiology ; Male ; Medicine ; Microneurography ; Middle Aged ; Muscle, Skeletal - blood supply ; Muscle, Skeletal - innervation ; Muscle, Skeletal - physiology ; Nitric oxide ; Regional analysis ; Regional Blood Flow - physiology ; Resistance ; Rodents ; Sympathetic Nervous System - blood supply ; Sympathetic Nervous System - physiology ; Vascular Resistance - physiology</subject><ispartof>PloS one, 2013-01, Vol.8 (1), p.e53769-e53769</ispartof><rights>COPYRIGHT 2013 Public Library of Science</rights><rights>2013 Tan et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2013 Tan et al 2013 Tan et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-a23dbeeebd46180e877d727d327fd9db725681256ba82e40a3c5f574716e91d73</citedby><cites>FETCH-LOGICAL-c692t-a23dbeeebd46180e877d727d327fd9db725681256ba82e40a3c5f574716e91d73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3542370/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3542370/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2095,2914,23846,27903,27904,53770,53772,79347,79348</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23326501$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Bearden, Shawn E.</contributor><creatorcontrib>Tan, Can Ozan</creatorcontrib><creatorcontrib>Tamisier, Renaud</creatorcontrib><creatorcontrib>Hamner, J W</creatorcontrib><creatorcontrib>Taylor, J Andrew</creatorcontrib><title>Characterizing sympathetic neurovascular transduction in humans</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Despite its critical role for cardiovascular homeostasis in humans, only a few studies have directly probed the transduction of sympathetic nerve activity to regional vascular responses--sympathetic neurovascular transduction. Those that have variably relied on either vascular resistance or vascular conductance to quantify the responses. However, it remains unclear which approach would better reflect the physiology. We assessed the utility of both of these as well as an alternative approach in 21 healthy men. We recorded arterial pressure (Finapres), peroneal sympathetic nerve activity (microneurography), and popliteal blood flow (Doppler) during isometric handgrip exercise to fatigue. We quantified and compared transduction via the relation of sympathetic activity to resistance and to conductance and via an adaptation of Poiseuille's relation including pressure, sympathetic activity, and flow. The average relationship between sympathetic activity and resistance (or conductance) was good when assessed over 30-second averages (mean R(2) = 0.49±0.07) but lesser when incorporating beat-by-beat time lags (R(2) = 0.37±0.06). However, in a third of the subjects, these relations provided relatively weak estimates (R(2)<0.33). In contrast, the Poiseuille relation reflected vascular responses more accurately (R(2) = 0.77±0.03, >0.50 in 20 of 21 individuals), and provided reproducible estimates of transduction. The gain derived from the relation of resistance (but not conductance) was inversely related to transduction (R(2) = 0.37, p<0.05), but with a proportional bias. 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blood supply</subject><subject>Muscle, Skeletal - innervation</subject><subject>Muscle, Skeletal - physiology</subject><subject>Nitric oxide</subject><subject>Regional analysis</subject><subject>Regional Blood Flow - physiology</subject><subject>Resistance</subject><subject>Rodents</subject><subject>Sympathetic Nervous System - blood supply</subject><subject>Sympathetic Nervous System - physiology</subject><subject>Vascular Resistance - physiology</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNkl2L1DAUhoso7jr6D0QHBNGLGfPRJs2Nsgx-DCws-HUbTpN0mqVNZpN2cf31pk53mcpeSCENp895c970zbLnGK0x5fjdpR-Cg3a9986sESooZ-JBdooFJStGEH14tD_JnsR4OUIlY4-zE0IpYQXCp9mHTQMBVG-C_W3dbhlvuj30jemtWjozBH8NUQ0thGUfwEU9qN56t7Ru2QxdKjzNHtXQRvNsei-yH58-ft98WZ1ffN5uzs5XignSr4BQXRljKp0zXCJTcq454ZoSXmuhK04KVuK0VFASkyOgqqgLnnPMjMCa00X28qC7b32Uk_coMSkF4ggXKBHbA6E9XMp9sB2EG-nByr8FH3YSQrLVGmkEMK6VoUBRLtKEvBLjBAQKXAMRSev9dNpQdSaRLrlvZ6LzL842cuevJS1yQvk4zJtJIPirwcRedjYq07bgjB_GuTllRJCSJPTVP-j97iZqB8mAdbVP56pRVJ7lvKR5Ma6LbH0PlR5tOqtSUGqb6rOGt7OGxPTmV7-DIUa5_fb1_9mLn3P29RHbGGj7Jvp2GMMT52B-AFXwMQZT310yRnLM-e1tyDHncsp5antx_IPumm6DTf8AFv73sg</recordid><startdate>20130110</startdate><enddate>20130110</enddate><creator>Tan, Can Ozan</creator><creator>Tamisier, Renaud</creator><creator>Hamner, J W</creator><creator>Taylor, J Andrew</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20130110</creationdate><title>Characterizing sympathetic neurovascular transduction in humans</title><author>Tan, Can Ozan ; Tamisier, Renaud ; Hamner, J W ; Taylor, J Andrew</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-a23dbeeebd46180e877d727d327fd9db725681256ba82e40a3c5f574716e91d73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Arterial Pressure - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tan, Can Ozan</au><au>Tamisier, Renaud</au><au>Hamner, J W</au><au>Taylor, J Andrew</au><au>Bearden, Shawn E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characterizing sympathetic neurovascular transduction in humans</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2013-01-10</date><risdate>2013</risdate><volume>8</volume><issue>1</issue><spage>e53769</spage><epage>e53769</epage><pages>e53769-e53769</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Despite its critical role for cardiovascular homeostasis in humans, only a few studies have directly probed the transduction of sympathetic nerve activity to regional vascular responses--sympathetic neurovascular transduction. Those that have variably relied on either vascular resistance or vascular conductance to quantify the responses. However, it remains unclear which approach would better reflect the physiology. We assessed the utility of both of these as well as an alternative approach in 21 healthy men. We recorded arterial pressure (Finapres), peroneal sympathetic nerve activity (microneurography), and popliteal blood flow (Doppler) during isometric handgrip exercise to fatigue. We quantified and compared transduction via the relation of sympathetic activity to resistance and to conductance and via an adaptation of Poiseuille's relation including pressure, sympathetic activity, and flow. The average relationship between sympathetic activity and resistance (or conductance) was good when assessed over 30-second averages (mean R(2) = 0.49±0.07) but lesser when incorporating beat-by-beat time lags (R(2) = 0.37±0.06). However, in a third of the subjects, these relations provided relatively weak estimates (R(2)<0.33). In contrast, the Poiseuille relation reflected vascular responses more accurately (R(2) = 0.77±0.03, >0.50 in 20 of 21 individuals), and provided reproducible estimates of transduction. The gain derived from the relation of resistance (but not conductance) was inversely related to transduction (R(2) = 0.37, p<0.05), but with a proportional bias. Thus, vascular resistance and conductance may not always be reliable surrogates for regional sympathetic neurovascular transduction, and assessment from a Poiseuille relation between pressure, sympathetic nerve activity, and flow may provide a better foundation to further explore differences in transduction in humans.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23326501</pmid><doi>10.1371/journal.pone.0053769</doi><tpages>e53769</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Arterial Pressure - physiology Biology Blood flow Blood pressure Circulatory system Conductance Exercise - physiology Fatigue Hand Strength - physiology Hemodynamics Homeostasis Humans Isometric Leg - blood supply Leg - physiology Male Medicine Microneurography Middle Aged Muscle, Skeletal - blood supply Muscle, Skeletal - innervation Muscle, Skeletal - physiology Nitric oxide Regional analysis Regional Blood Flow - physiology Resistance Rodents Sympathetic Nervous System - blood supply Sympathetic Nervous System - physiology Vascular Resistance - physiology |
| title | Characterizing sympathetic neurovascular transduction in humans |
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