Whole-brain functional networks in cognitively normal, mild cognitive impairment, and Alzheimer's disease
The conceptual significance of understanding functional brain alterations and cognitive deficits associated with Alzheimer's disease (AD) process has been widely established. However, the whole-brain functional networks of AD and its prodromal stage, mild cognitive impairment (MCI), are not wel...
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| description | The conceptual significance of understanding functional brain alterations and cognitive deficits associated with Alzheimer's disease (AD) process has been widely established. However, the whole-brain functional networks of AD and its prodromal stage, mild cognitive impairment (MCI), are not well clarified yet. In this study, we compared the characteristics of the whole-brain functional networks among cognitively normal (CN), MCI, and AD individuals by applying graph theoretical analyses to [(18)F] fluorodeoxyglucose positron emission tomography (FDG-PET) data. Ninety-four CN elderly, 183 with MCI, and 216 with AD underwent clinical evaluation and FDG-PET scan. The overall small-world property as seen in the CN whole-brain network was preserved in MCI and AD. In contrast, individual parameters of the network were altered with the following patterns of changes: local clustering of networks was lower in both MCI and AD compared to CN, while path length was not different among the three groups. Then, MCI had a lower level of local clustering than AD. Subgroup analyses for AD also revealed that very mild AD had lower local clustering and shorter path length compared to mild AD. Regarding the local properties of the whole-brain networks, MCI and AD had significantly decreased normalized betweenness centrality in several hubs regionally associated with the default mode network compared to CN. Our results suggest that the functional integration in whole-brain network progressively declines due to the AD process. On the other hand, functional relatedness between neighboring brain regions may not gradually decrease, but be the most severely altered in MCI stage and gradually re-increase in clinical AD stages. |
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However, the whole-brain functional networks of AD and its prodromal stage, mild cognitive impairment (MCI), are not well clarified yet. In this study, we compared the characteristics of the whole-brain functional networks among cognitively normal (CN), MCI, and AD individuals by applying graph theoretical analyses to [(18)F] fluorodeoxyglucose positron emission tomography (FDG-PET) data. Ninety-four CN elderly, 183 with MCI, and 216 with AD underwent clinical evaluation and FDG-PET scan. The overall small-world property as seen in the CN whole-brain network was preserved in MCI and AD. In contrast, individual parameters of the network were altered with the following patterns of changes: local clustering of networks was lower in both MCI and AD compared to CN, while path length was not different among the three groups. Then, MCI had a lower level of local clustering than AD. Subgroup analyses for AD also revealed that very mild AD had lower local clustering and shorter path length compared to mild AD. Regarding the local properties of the whole-brain networks, MCI and AD had significantly decreased normalized betweenness centrality in several hubs regionally associated with the default mode network compared to CN. Our results suggest that the functional integration in whole-brain network progressively declines due to the AD process. On the other hand, functional relatedness between neighboring brain regions may not gradually decrease, but be the most severely altered in MCI stage and gradually re-increase in clinical AD stages.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0053922</identifier><identifier>PMID: 23335980</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Advertising executives ; Aged ; Alzheimer Disease - metabolism ; Alzheimer Disease - physiopathology ; Alzheimer's disease ; Biology ; Biomedical engineering ; Biomedical research ; Brain ; Brain - physiology ; Brain - physiopathology ; Brain Mapping ; Brain research ; Clustering ; Cognition - physiology ; Cognitive ability ; Cognitive Dysfunction - metabolism ; Cognitive Dysfunction - physiopathology ; Comparative analysis ; Dementia ; Emission analysis ; Female ; Fluorodeoxyglucose F18 ; Functional integration ; Geriatrics ; Hospitals ; Humans ; Impairment ; Interdisciplinary aspects ; Male ; Medical imaging ; Medicine ; Memory ; Metabolic Networks and Pathways ; Metabolism ; Middle Aged ; Networks ; Neural networks ; Neurodegenerative diseases ; Neurophysiology ; NMR ; Nuclear magnetic resonance ; Older people ; Positron emission ; Positron emission tomography ; Social and Behavioral Sciences ; Studies ; Tomography</subject><ispartof>PloS one, 2013-01, Vol.8 (1), p.e53922-e53922</ispartof><rights>COPYRIGHT 2013 Public Library of Science</rights><rights>2013 Seo et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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Subgroup analyses for AD also revealed that very mild AD had lower local clustering and shorter path length compared to mild AD. Regarding the local properties of the whole-brain networks, MCI and AD had significantly decreased normalized betweenness centrality in several hubs regionally associated with the default mode network compared to CN. Our results suggest that the functional integration in whole-brain network progressively declines due to the AD process. 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functional networks in cognitively normal, mild cognitive impairment, and Alzheimer's disease</title><author>Seo, Eun Hyun ; Lee, Dong Young ; Lee, Jong-Min ; Park, Jun-Sung ; Sohn, Bo Kyung ; Lee, Dong Soo ; Choe, Young Min ; Woo, Jong Inn</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6072-d6d2fab71696588fe8b048aa4f37ea94c23466d8198f11286df09810a4b7c7383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Advertising executives</topic><topic>Aged</topic><topic>Alzheimer Disease - metabolism</topic><topic>Alzheimer Disease - physiopathology</topic><topic>Alzheimer's disease</topic><topic>Biology</topic><topic>Biomedical engineering</topic><topic>Biomedical research</topic><topic>Brain</topic><topic>Brain - physiology</topic><topic>Brain - physiopathology</topic><topic>Brain Mapping</topic><topic>Brain research</topic><topic>Clustering</topic><topic>Cognition - 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cognitive deficits associated with Alzheimer's disease (AD) process has been widely established. However, the whole-brain functional networks of AD and its prodromal stage, mild cognitive impairment (MCI), are not well clarified yet. In this study, we compared the characteristics of the whole-brain functional networks among cognitively normal (CN), MCI, and AD individuals by applying graph theoretical analyses to [(18)F] fluorodeoxyglucose positron emission tomography (FDG-PET) data. Ninety-four CN elderly, 183 with MCI, and 216 with AD underwent clinical evaluation and FDG-PET scan. The overall small-world property as seen in the CN whole-brain network was preserved in MCI and AD. In contrast, individual parameters of the network were altered with the following patterns of changes: local clustering of networks was lower in both MCI and AD compared to CN, while path length was not different among the three groups. Then, MCI had a lower level of local clustering than AD. Subgroup analyses for AD also revealed that very mild AD had lower local clustering and shorter path length compared to mild AD. Regarding the local properties of the whole-brain networks, MCI and AD had significantly decreased normalized betweenness centrality in several hubs regionally associated with the default mode network compared to CN. Our results suggest that the functional integration in whole-brain network progressively declines due to the AD process. On the other hand, functional relatedness between neighboring brain regions may not gradually decrease, but be the most severely altered in MCI stage and gradually re-increase in clinical AD stages.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23335980</pmid><doi>10.1371/journal.pone.0053922</doi><tpages>e53922</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Advertising executives Aged Alzheimer Disease - metabolism Alzheimer Disease - physiopathology Alzheimer's disease Biology Biomedical engineering Biomedical research Brain Brain - physiology Brain - physiopathology Brain Mapping Brain research Clustering Cognition - physiology Cognitive ability Cognitive Dysfunction - metabolism Cognitive Dysfunction - physiopathology Comparative analysis Dementia Emission analysis Female Fluorodeoxyglucose F18 Functional integration Geriatrics Hospitals Humans Impairment Interdisciplinary aspects Male Medical imaging Medicine Memory Metabolic Networks and Pathways Metabolism Middle Aged Networks Neural networks Neurodegenerative diseases Neurophysiology NMR Nuclear magnetic resonance Older people Positron emission Positron emission tomography Social and Behavioral Sciences Studies Tomography |
| title | Whole-brain functional networks in cognitively normal, mild cognitive impairment, and Alzheimer's disease |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T18%3A06%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Whole-brain%20functional%20networks%20in%20cognitively%20normal,%20mild%20cognitive%20impairment,%20and%20Alzheimer's%20disease&rft.jtitle=PloS%20one&rft.au=Seo,%20Eun%20Hyun&rft.date=2013-01-15&rft.volume=8&rft.issue=1&rft.spage=e53922&rft.epage=e53922&rft.pages=e53922-e53922&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0053922&rft_dat=%3Cgale_plos_%3EA478270124%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1289070015&rft_id=info:pmid/23335980&rft_galeid=A478270124&rft_doaj_id=oai_doaj_org_article_280542cf575249019c5f5b7cb869d2b1&rfr_iscdi=true |