Inhibitors of pathogen intercellular signals as selective anti-infective compounds

Long-term antibiotic use generates pan-resistant super pathogens. Anti-infective compounds that selectively disrupt virulence pathways without affecting cell viability may be used to efficiently combat infections caused by these pathogens. A candidate target pathway is quorum sensing (QS), which man...

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Veröffentlicht in:	PLoS pathogens 2007-09, Vol.3 (9), p.1229-1239
Hauptverfasser:	Lesic, Biliana, Lépine, François, Déziel, Eric, Zhang, Jiangwen, Zhang, Qunhao, Padfield, Katie, Castonguay, Marie-Hélène, Milot, Sylvain, Stachel, Scott, Tzika, A Aria, Tompkins, Ronald G, Rahme, Laurence G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use Antibiotics Bacterial infections Bacteriology Biosynthesis Cell Survival - physiology Chemical Biology Communications systems Drug resistance Experiments Gene Expression Regulation, Bacterial Genetic aspects Health aspects In Vitro Infections Infectious Diseases Methods Mice Mice, Inbred Strains Microbiology Mortality Mus (mouse) NMR Nuclear magnetic resonance ortho-Aminobenzoates - chemistry ortho-Aminobenzoates - metabolism Pathogenesis Pathogens Population density Pseudomonas aeruginosa Pseudomonas aeruginosa - genetics Pseudomonas aeruginosa - physiology Pseudomonas Infections - drug therapy Quinolines - metabolism Quorum sensing Quorum Sensing - drug effects Quorum Sensing - physiology Regulation Virulence Virus Cultivation
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