An accessory to the 'Trinity': SR-As are essential pathogen sensors of extracellular dsRNA, mediating entry and leading to subsequent type I IFN responses

Extracellular RNA is becoming increasingly recognized as a signaling molecule. Virally derived double stranded (ds)RNA released into the extracellular space during virus induced cell lysis acts as a powerful inducer of classical type I interferon (IFN) responses; however, the receptor that mediates...

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Veröffentlicht in:	PLoS pathogens 2010-03, Vol.6 (3), p.e1000829-e1000829
Hauptverfasser:	DeWitte-Orr, Stephanie J, Collins, Susan E, Bauer, Carla M T, Bowdish, Dawn M, Mossman, Karen L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line Development and progression Extracellular Space - genetics Fibroblasts - cytology Fluorides Gene Knockdown Techniques Genetic aspects Humans Immune response Immune system Immunology/Immunity to Infections Immunology/Innate Immunity Infections Infectious Diseases/Viral Infections Interferon Interferon Type I - metabolism Medical research Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Monocytes - cytology NOD-like receptors Physiological aspects RNA RNA, Double-Stranded - metabolism RNA, Viral - metabolism Scavenger Receptors, Class A - genetics Scavenger Receptors, Class A - immunology Scavenger Receptors, Class A - metabolism Sensors Statistical analysis Toll-Like Receptor 3 - immunology Viral infections Virology/Host Antiviral Responses Virus diseases Virus Diseases - immunology
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