BDNF regulates the expression and distribution of vesicular glutamate transporters in cultured hippocampal neurons

BDNF is a pro-survival protein involved in neuronal development and synaptic plasticity. BDNF strengthens excitatory synapses and contributes to LTP, presynaptically, through enhancement of glutamate release, and postsynaptically, via phosphorylation of neurotransmitter receptors, modulation of rece...

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Veröffentlicht in:	PloS one 2013-01, Vol.8 (1), p.e53793
Hauptverfasser:	Melo, Carlos V, Mele, Miranda, Curcio, Michele, Comprido, Diogo, Silva, Carla G, Duarte, Carlos B
Format:	Artikel
Sprache:	eng
Schlagworte:	Actinomycin Animals Anisomycin Anisomycin - pharmacology Apoptosis Axons Biochemistry, biophysics & molecular biology Biochimie, biophysique & biologie moléculaire Biology Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - genetics Brain-Derived Neurotrophic Factor - metabolism Cell survival Cells, Cultured Dactinomycin - pharmacology Developmental plasticity Embryogenesis Embryonic development Emetine Fibroblast growth factor 2 Fibroblast growth factors Fluorescence Fluorescence microscopy Gene expression Gene Expression Regulation, Developmental Gene regulation Genes Glutamate Glutamate receptors Glutamic Acid - genetics Glutamic Acid - metabolism Glutamic acid receptors Hippocampus Hippocampus - cytology Hippocampus - metabolism Immunoblotting Inhibition Insulin-like growth factor I Isoforms Kinases Life sciences Long-term potentiation Long-Term Potentiation - genetics Long-Term Potentiation - physiology Machinery and equipment Memory Neonates Neurites - metabolism Neuromodulation Neuronal Plasticity - genetics Neurons Neurons - cytology Neurons - metabolism Neurosciences Neurotransmitter receptors Phosphorylation Protein synthesis Protein transport Proteins Rats Receptors RNA Rodents Sciences du vivant Signaling Stimulation Synapses Synapses - genetics Synapses - metabolism Synaptic plasticity Synaptogenesis Transcription Translation Translation (Genetics) Tyrosine Up-Regulation - drug effects Vesicular Glutamate Transport Protein 1 - genetics Vesicular Glutamate Transport Protein 1 - metabolism Vesicular Glutamate Transport Protein 2 - genetics Vesicular Glutamate Transport Protein 2 - metabolism
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