Differential regulation of effector- and central-memory responses to Toxoplasma gondii Infection by IL-12 revealed by tracking of Tgd057-specific CD8+ T cells

Production of the pro-inflammatory cytokine IL-12 by innate phagocytes drives the differentiation of IFN-gamma-producing effector T cells during Toxoplasma gondii infection. However, the role of IL-12 in the regulation of memory CD8+ T cell differentiation and function during murine toxoplasmosis is...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PLoS pathogens 2010-03, Vol.6 (3), p.e1000815-e1000815
Hauptverfasser:	Wilson, Douglas C, Grotenbreg, Gijsbert M, Liu, Kenian, Zhao, Yanlin, Frickel, Eva-Maria, Gubbels, Marc-Jan, Ploegh, Hidde L, Yap, George S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Protozoan - immunology Causes of CD8 lymphocytes CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - parasitology Cell Differentiation - immunology Development and progression Epitopes Genetic aspects Immune system Immunologic Memory - immunology Immunology Immunology/Cellular Microbiology and Pathogenesis Immunology/Immune Response Immunology/Immunity to Infections Immunology/Leukocyte Activation Immunophenotyping Infections Infectious Diseases/Protozoal Infections Interleukin-12 Interleukin-12 - genetics Interleukin-12 - immunology Interleukin-12 - metabolism Mice Mice, Inbred C57BL Mice, Mutant Strains Parasites Physiological aspects Proteins Rodents Signal Transduction - immunology Toxoplasma Toxoplasma - immunology Toxoplasmosis Toxoplasmosis, Animal - immunology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!