Human cytomegalovirus UL29/28 protein interacts with components of the NuRD complex which promote accumulation of immediate-early RNA

Histone deacetylation plays a pivotal role in regulating human cytomegalovirus gene expression. In this report, we have identified candidate HDAC1-interacting proteins in the context of infection by using a method for rapid immunoisolation of an epitope-tagged protein coupled with mass spectrometry....

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Veröffentlicht in:	PLoS pathogens 2010-06, Vol.6 (6), p.e1000965-e1000965
Hauptverfasser:	Terhune, Scott S, Moorman, Nathaniel J, Cristea, Ileana M, Savaryn, John Paul, Cuevas-Bennett, Christian, Rout, Michael P, Chait, Brian T, Shenk, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Autoantigens - genetics Autoantigens - metabolism Biophysics/Protein Chemistry and Proteomics Biotechnology/Protein Chemistry and Proteomics Blotting, Western Cancer Cells, Cultured Chromatin Chromatin Immunoprecipitation Cytomegalovirus Cytomegalovirus - pathogenicity Cytomegalovirus Infections - genetics Cytomegalovirus Infections - metabolism Cytomegalovirus Infections - virology Cytomegaloviruses Deacetylation Differentiation DNA Enzymes Fibroblasts - cytology Fibroblasts - drug effects Fibroblasts - metabolism Fluorescent Antibody Technique Gene expression Genetic aspects Genetics Genomes HDAC1 protein Health aspects Herpesvirus Histone acetyltransferase Histone deacetylase Histone Deacetylase 1 - antagonists & inhibitors Histone Deacetylase 1 - genetics Histone Deacetylase 1 - metabolism Histone Deacetylase Inhibitors - pharmacology Histone Deacetylases - genetics Histone Deacetylases - metabolism Histones Host-pathogen interactions Human cytomegalovirus Humans Hydroxamic Acids - pharmacology Immediate-Early Proteins - genetics Immunoprecipitation Infection Infectious Diseases Luciferases - metabolism Mass spectrometry Mass spectroscopy Mi-2 Nucleosome Remodeling and Deacetylase Complex - antagonists & inhibitors Mi-2 Nucleosome Remodeling and Deacetylase Complex - genetics Mi-2 Nucleosome Remodeling and Deacetylase Complex - metabolism Microbiology Molecular Biology/Transcription Initiation and Activation Molecular weight Nucleosomes NuRD protein Pathogens Peptides Persistent infection Physiological aspects Promoter Regions, Genetic Promoters Proteins proteomics Replication Repressor Proteins - genetics Repressor Proteins - metabolism Retinoblastoma-Binding Protein 4 - genetics Retinoblastoma-Binding Protein 4 - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA RNA, Messenger - genetics RNA, Viral - genetics Trichostatin A Viral proteins Viral Proteins - genetics Viral Proteins - metabolism Virology Virology/Viral and Gene Regulation Virology/Virulence Factors and Mechanisms Virus Replication
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