Low formalin concentrations induce fine-tuned responses that are sex and age-dependent: a developmental study

The formalin test is increasingly applied as a model of inflammatory pain using high formalin concentrations (5-15%). However, little is known about the effects of low formalin concentrations on related behavioural responses. To examine this, rat pups were subjected to various concentrations of form...

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Veröffentlicht in:	PloS one 2013-01, Vol.8 (1), p.e53384
Hauptverfasser:	Zouikr, Ihssane, Tadros, Melissa A, Clifton, Vicki L, Beagley, Kenneth W, Hodgson, Deborah M
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Age Factors Analysis Animals Animals, Newborn Behavior, Animal - drug effects Behavior, Animal - physiology Biology Developmental stages Dose-Response Relationship, Drug Female Females Formaldehyde Formaldehyde - pharmacology Gender aspects Inflammation Injections, Subcutaneous Laboratories Male Males Neurosciences Nociception - drug effects Nociception - physiology Pain Pain - physiopathology Pain Measurement Pain perception Rats Rats, Wistar Rodents Sex Sex differences Sex Factors Social and Behavioral Sciences Spinal cord Time Factors Veterinary Science
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