Temporal proteome and lipidome profiles reveal hepatitis C virus-associated reprogramming of hepatocellular metabolism and bioenergetics

Proteomic and lipidomic profiling was performed over a time course of acute hepatitis C virus (HCV) infection in cultured Huh-7.5 cells to gain new insights into the intracellular processes influenced by this virus. Our proteomic data suggest that HCV induces early perturbations in glycolysis, the p...

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Veröffentlicht in:	PLoS pathogens 2010-01, Vol.6 (1), p.e1000719-e1000719
Hauptverfasser:	Diamond, Deborah L, Syder, Andrew J, Jacobs, Jon M, Sorensen, Christina M, Walters, Kathie-Anne, Proll, Sean C, McDermott, Jason E, Gritsenko, Marina A, Zhang, Qibin, Zhao, Rui, Metz, Thomas O, Camp, 2nd, David G, Waters, Katrina M, Smith, Richard D, Rice, Charles M, Katze, Michael G
Format:	Artikel
Sprache:	eng
Schlagworte:	Biosynthesis Cell culture Cell Line, Tumor Cholesterol Chromatography, Liquid Computational Biology Energy Metabolism - physiology Gastroenterology and Hepatology/Hepatology Health aspects Hepacivirus - physiology Hepatitis Hepatitis C virus Hepatoma Homeostasis Humans Infectious Diseases Infectious Diseases/Viral Infections Lipid metabolism Lipids - analysis Liver - metabolism Liver - virology Liver diseases Low density lipoprotein Mass Spectrometry Metabolism Molecular weight Pathogenesis Physiological aspects Propagation Proteins Proteins - analysis Proteins - metabolism Proteome Proteomics Risk factors Virus Replication Viruses
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