Hsmar1 transposition is sensitive to the topology of the transposon donor and the target

Hsmar1 is a member of the Tc1-mariner superfamily of DNA transposons. These elements mobilize within the genome of their host by a cut-and-paste mechanism. We have exploited the in vitro reaction provided by Hsmar1 to investigate the effect of DNA supercoiling on transposon integration. We found tha...

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Veröffentlicht in:	PloS one 2013-01, Vol.8 (1), p.e53690
Hauptverfasser:	Claeys Bouuaert, Corentin, Chalmers, Ronald
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Bias Biology Defects Deoxyribonucleic acid DNA DNA Transposable Elements - genetics DNA, Superhelical - chemistry DNA, Superhelical - genetics DNA, Superhelical - metabolism Gene therapy Genetic engineering Genomes Genomics Integration Mutagenesis, Insertional Plasmids Site selection Substrates Supercoiling Topology Transposition Transposons
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