A novel regulatory function of sweet taste-sensing receptor in adipogenic differentiation of 3T3-L1 cells

Sweet taste receptor is expressed not only in taste buds but also in nongustatory organs such as enteroendocrine cells and pancreatic beta-cells, and may play more extensive physiological roles in energy metabolism. Here we examined the expression and function of the sweet taste receptor in 3T3-L1 c...

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Veröffentlicht in:	PloS one 2013-01, Vol.8 (1), p.e54500-e54500
Hauptverfasser:	Masubuchi, Yosuke, Nakagawa, Yuko, Ma, Jinhui, Sasaki, Tsutomu, Kitamura, Tadahiro, Yamamoto, Yoritsuna, Kurose, Hitoshi, Kojima, Itaru, Shibata, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3-L1 Cells Activation Adenylate cyclase Adipocytes Adipocytes - cytology Adipocytes - metabolism Adipogenesis - genetics Animals Beta cells Biology CCAAT/enhancer-binding protein Cell Differentiation - genetics Cell Line Cholera Cholera toxin Cloning Cyclic adenosine monophosphate Cyclic AMP Cyclic AMP - metabolism Detection Differentiation Energy metabolism Experiments Forskolin Gene Expression Gnat3 protein GTP-Binding Proteins - genetics GTP-Binding Proteins - metabolism Humans Infections Insulin Kinases Male Medicine Metabolism Mice Organs Pancreas Pancreatic beta cells Preadipocytes Protein binding Proteins Public health Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism Regulation Ribonucleic acid RNA RNA-mediated interference Rodents Saccharin Signal transduction siRNA Sucralose Sweet taste Sweeteners Taste Taste (Sense) Taste buds Taste Buds - physiology Taste receptors Triglycerides Waterborne diseases
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