Structure-based stabilization of HIV-1 gp120 enhances humoral immune responses to the induced co-receptor binding site

The human immunodeficiency virus type 1 (HIV-1) exterior envelope glycoprotein, gp120, possesses conserved binding sites for interaction with the primary virus receptor, CD4, and also for the co-receptor, generally CCR5. Although gp120 is a major target for virus-specific neutralizing antibodies, th...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PLoS pathogens 2009-05, Vol.5 (5), p.e1000445-e1000445
Hauptverfasser:	Dey, Barna, Svehla, Krisha, Xu, Ling, Wycuff, Dianne, Zhou, Tongqing, Voss, Gerald, Phogat, Adhuna, Chakrabarti, Bimal K, Li, Yuxing, Shaw, George, Kwong, Peter D, Nabel, Gary J, Mascola, John R, Wyatt, Richard T
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS Vaccines Animals Antibody Formation Binding sites Binding Sites - immunology Biophysics/Biomacromolecule-Ligand Interactions CD4 Antigens - immunology Development and progression HIV HIV Envelope Protein gp120 - genetics HIV Envelope Protein gp120 - immunology HIV Envelope Protein gp120 - metabolism HIV infection Human immunodeficiency virus Humans Immune response Immunology/Immune Response Ligands Mortality Pandemics Physiological aspects Protein Conformation Protein Engineering Protein Stability Proteins Rabbits Receptors Receptors, CCR5 - metabolism Receptors, HIV - metabolism Vaccines Values Viral proteins Virology Virology/Immune Evasion Virology/Immunodeficiency Viruses Viruses
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!