Immunogenicity and protective efficacy of a live attenuated H5N1 vaccine in nonhuman primates

The continued spread of highly pathogenic H5N1 influenza viruses among poultry and wild birds, together with the emergence of drug-resistant variants and the possibility of human-to-human transmission, has spurred attempts to develop an effective vaccine. Inactivated subvirion or whole-virion H5N1 v...

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Veröffentlicht in:	PLoS pathogens 2009-05, Vol.5 (5), p.e1000409-e1000409
Hauptverfasser:	Fan, Shufang, Gao, Yuwei, Shinya, Kyoko, Li, Chris Kafai, Li, Yanbing, Shi, Jianzhong, Jiang, Yongping, Suo, Yongbing, Tong, Tiegang, Zhong, Gongxun, Song, Jiasheng, Zhang, Ying, Tian, Guobin, Guan, Yuntao, Xu, Xiao-Ning, Bu, Zhigao, Kawaoka, Yoshihiro, Chen, Hualan
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intranasal Animals Antibodies, Viral - blood Avian influenza Birds Body Temperature Causes of Drug resistance Fatalities Female Immune response Infections Influenza A Virus, H5N1 Subtype - immunology Influenza A Virus, H5N1 Subtype - physiology Influenza vaccines Influenza Vaccines - immunology Influenza virus Injections, Intravenous Macaca mulatta Mice Mice, Inbred BALB C Monkeys & apes Mustela Orthomyxoviridae Infections - prevention & control Orthomyxoviridae Infections - virology Pandemics Physiological aspects Prevention Primates Production capacity Properties Reassortant Viruses - immunology Respiratory system Statistical analysis T-Lymphocytes - immunology Vaccination Vaccines Vaccines, Attenuated - immunology Viral Load Virology/Vaccines Virus Replication Virus Shedding Viruses
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