A protective role for ELR+ chemokines during acute viral encephalomyelitis

The functional role of ELR-positive CXC chemokines in host defense during acute viral-induced encephalomyelitis was determined. Inoculation of the neurotropic JHM strain of mouse hepatitis virus (JHMV) into the central nervous system (CNS) of mice resulted in the rapid mobilization of PMNs expressin...

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Veröffentlicht in:	PLoS pathogens 2009-11, Vol.5 (11), p.e1000648-e1000648
Hauptverfasser:	Hosking, Martin P, Liu, Liping, Ransohoff, Richard M, Lane, Thomas E
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Animals Bacterial infections Brain Brain Chemistry Chemokine CXCL1 Chemokine CXCL2 Chemokine CXCL5 Chemokines Chemokines, CXC - biosynthesis Chemokines, CXC - immunology Encephalomyelitis Encephalomyelitis - immunology Encephalomyelitis - virology Experiments Health aspects Hepatitis Immune response Ligands Lymphocytes Mice Mice, Knockout Migration Mortality Murine hepatitis virus Neutrophil Infiltration - immunology Poliovirus Receptors, Interleukin-8B - deficiency Receptors, Interleukin-8B - immunology Risk factors Rodents T-Lymphocytes - immunology Viral infections Virology/Animal Models of Infection Virus Replication
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