Pandemic vaccine preparedness--have we left something behind?
Since 1997, most scientific studies have focused on avian H5, and to a minor extent avian H7 and H9 subtype viruses, because these viruses have caused repeated zoonotic human infections and have spread widely in poultry over the past 10 years or more. There are significant antigenic differences wi...
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Since 1997, most scientific studies have focused on avian H5, and to a minor extent avian H7 and H9 subtype viruses, because these viruses have caused repeated zoonotic human infections and have spread widely in poultry over the past 10 years or more. There are significant antigenic differences within subtypes that change over time as these viruses evolve, and this requires a semi-annual review and frequent update of vaccine strain candidates for human seasonal influenza vaccines. |
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Since 1997, most scientific studies have focused on avian H5, and to a minor extent avian H7 and H9 subtype viruses, because these viruses have caused repeated zoonotic human infections and have spread widely in poultry over the past 10 years or more. There are significant antigenic differences within subtypes that change over time as these viruses evolve, and this requires a semi-annual review and frequent update of vaccine strain candidates for human seasonal influenza vaccines.</description><identifier>ISSN: 1553-7374</identifier><identifier>ISSN: 1553-7366</identifier><identifier>EISSN: 1553-7374</identifier><identifier>DOI: 10.1371/journal.ppat.1000482</identifier><identifier>PMID: 19557166</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Animals ; Antigens, Viral - immunology ; Birds ; Causes of ; Disaster Planning ; Disease Outbreaks - prevention & control ; Emergency management ; Health aspects ; Hemagglutination Inhibition Tests ; Humans ; Immunization ; Influenza ; Influenza A virus - immunology ; Influenza A Virus, H1N1 Subtype - immunology ; Influenza A Virus, H2N2 Subtype - immunology ; Influenza A Virus, H3N2 Subtype - immunology ; Influenza in Birds - virology ; Influenza vaccines ; Influenza Vaccines - administration & dosage ; Influenza Vaccines - immunology ; Influenza, Human - prevention & control ; Influenza, Human - virology ; Methods ; Middle Aged ; Opinion ; Pandemics ; Prevention ; Public health ; Vaccines ; Virology ; Virology/Immune Evasion ; Virology/Vaccines</subject><ispartof>PLoS pathogens, 2009-06, Vol.5 (6), p.e1000482-e1000482</ispartof><rights>COPYRIGHT 2009 Public Library of Science</rights><rights>Capua et al. 2009</rights><rights>2009 Capua et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Capua I, Kajaste-Rudnitski A, Bertoli E, Vicenzi E (2009) Pandemic Vaccine Preparedness--Have We Left Something Behind? PLoS Pathog 5(6): e1000482. doi:10.1371/journal.ppat.1000482</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c631t-a6f17cfebcdf28f7e3b0da8d4581ee2dbe692f469cc74ab80b12353c59df30dc3</citedby><cites>FETCH-LOGICAL-c631t-a6f17cfebcdf28f7e3b0da8d4581ee2dbe692f469cc74ab80b12353c59df30dc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2696042/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2696042/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19557166$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Capua, Ilaria</creatorcontrib><creatorcontrib>Kajaste-Rudnitski, Anna</creatorcontrib><creatorcontrib>Bertoli, Elena</creatorcontrib><creatorcontrib>Vicenzi, Elisa</creatorcontrib><title>Pandemic vaccine preparedness--have we left something behind?</title><title>PLoS pathogens</title><addtitle>PLoS Pathog</addtitle><description>
Since 1997, most scientific studies have focused on avian H5, and to a minor extent avian H7 and H9 subtype viruses, because these viruses have caused repeated zoonotic human infections and have spread widely in poultry over the past 10 years or more. There are significant antigenic differences within subtypes that change over time as these viruses evolve, and this requires a semi-annual review and frequent update of vaccine strain candidates for human seasonal influenza vaccines.</description><subject>Adult</subject><subject>Animals</subject><subject>Antigens, Viral - immunology</subject><subject>Birds</subject><subject>Causes of</subject><subject>Disaster Planning</subject><subject>Disease Outbreaks - prevention & control</subject><subject>Emergency management</subject><subject>Health aspects</subject><subject>Hemagglutination Inhibition Tests</subject><subject>Humans</subject><subject>Immunization</subject><subject>Influenza</subject><subject>Influenza A virus - immunology</subject><subject>Influenza A Virus, H1N1 Subtype - immunology</subject><subject>Influenza A Virus, H2N2 Subtype - immunology</subject><subject>Influenza A Virus, H3N2 Subtype - immunology</subject><subject>Influenza in Birds - virology</subject><subject>Influenza vaccines</subject><subject>Influenza Vaccines - administration & dosage</subject><subject>Influenza Vaccines - immunology</subject><subject>Influenza, Human - prevention & control</subject><subject>Influenza, Human - virology</subject><subject>Methods</subject><subject>Middle Aged</subject><subject>Opinion</subject><subject>Pandemics</subject><subject>Prevention</subject><subject>Public health</subject><subject>Vaccines</subject><subject>Virology</subject><subject>Virology/Immune Evasion</subject><subject>Virology/Vaccines</subject><issn>1553-7374</issn><issn>1553-7366</issn><issn>1553-7374</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>DOA</sourceid><recordid>eNqVkluL1DAUx4so7kW_gWhBEHzomHvaB5Vl8TKwqHh5Dmly0unQNjVpZ_Xbm9mpugO-SB5OOPmdf05O_ln2CKMVphK_2Po5DLpbjaOeVhghxEpyJzvFnNNCUsnu3tqfZGcxbhOCKRb3sxNccS6xEKfZy096sNC3Jt9pY9oB8jHAqAPYAWIsio3eQX4NeQduyqPvYdq0Q5PXkIJ9_SC753QX4eESz7Nvb998vXxfXH18t768uCqMoHgqtHBYGge1sY6UTgKtkdWlZbzEAMTWICrimKiMkUzXJaoxoZwaXllHkTX0PHty0B07H9Xy8qgwKSvEORI8EesDYb3eqjG0vQ4_ldetukn40CgdptZ0oEomK4EMBVZXjFGoUGm4RRXBhlqsUdJ6tdw21z1YA8MUdHckenwytBvV-J0iIgkzkgSeLQLBf58hTqpvo4Gu0wP4OSohGcGS7Lt-egAbnRprB-eTntnD6oIgSiQm1b6f1T-otG4-zg_g2pQ_Knh-VJCYCX5MjZ5jVOsvn_-D_XDMsgNrgo8xgPszE4zU3pS_v0btTakWU6ayx7fn-bdocSH9BZep3Tg</recordid><startdate>20090601</startdate><enddate>20090601</enddate><creator>Capua, Ilaria</creator><creator>Kajaste-Rudnitski, Anna</creator><creator>Bertoli, Elena</creator><creator>Vicenzi, Elisa</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISN</scope><scope>ISR</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20090601</creationdate><title>Pandemic vaccine preparedness--have we left something behind?</title><author>Capua, Ilaria ; Kajaste-Rudnitski, Anna ; Bertoli, Elena ; Vicenzi, Elisa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c631t-a6f17cfebcdf28f7e3b0da8d4581ee2dbe692f469cc74ab80b12353c59df30dc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Animals</topic><topic>Antigens, Viral - immunology</topic><topic>Birds</topic><topic>Causes of</topic><topic>Disaster Planning</topic><topic>Disease Outbreaks - prevention & control</topic><topic>Emergency management</topic><topic>Health aspects</topic><topic>Hemagglutination Inhibition Tests</topic><topic>Humans</topic><topic>Immunization</topic><topic>Influenza</topic><topic>Influenza A virus - immunology</topic><topic>Influenza A Virus, H1N1 Subtype - immunology</topic><topic>Influenza A Virus, H2N2 Subtype - immunology</topic><topic>Influenza A Virus, H3N2 Subtype - immunology</topic><topic>Influenza in Birds - virology</topic><topic>Influenza vaccines</topic><topic>Influenza Vaccines - administration & dosage</topic><topic>Influenza Vaccines - immunology</topic><topic>Influenza, Human - prevention & control</topic><topic>Influenza, Human - virology</topic><topic>Methods</topic><topic>Middle Aged</topic><topic>Opinion</topic><topic>Pandemics</topic><topic>Prevention</topic><topic>Public health</topic><topic>Vaccines</topic><topic>Virology</topic><topic>Virology/Immune Evasion</topic><topic>Virology/Vaccines</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Capua, Ilaria</creatorcontrib><creatorcontrib>Kajaste-Rudnitski, Anna</creatorcontrib><creatorcontrib>Bertoli, Elena</creatorcontrib><creatorcontrib>Vicenzi, Elisa</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Canada</collection><collection>Gale In Context: Science</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PLoS pathogens</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Capua, Ilaria</au><au>Kajaste-Rudnitski, Anna</au><au>Bertoli, Elena</au><au>Vicenzi, Elisa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pandemic vaccine preparedness--have we left something behind?</atitle><jtitle>PLoS pathogens</jtitle><addtitle>PLoS Pathog</addtitle><date>2009-06-01</date><risdate>2009</risdate><volume>5</volume><issue>6</issue><spage>e1000482</spage><epage>e1000482</epage><pages>e1000482-e1000482</pages><issn>1553-7374</issn><issn>1553-7366</issn><eissn>1553-7374</eissn><abstract>
Since 1997, most scientific studies have focused on avian H5, and to a minor extent avian H7 and H9 subtype viruses, because these viruses have caused repeated zoonotic human infections and have spread widely in poultry over the past 10 years or more. There are significant antigenic differences within subtypes that change over time as these viruses evolve, and this requires a semi-annual review and frequent update of vaccine strain candidates for human seasonal influenza vaccines.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>19557166</pmid><doi>10.1371/journal.ppat.1000482</doi><oa>free_for_read</oa></addata></record> |
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subjects | Adult Animals Antigens, Viral - immunology Birds Causes of Disaster Planning Disease Outbreaks - prevention & control Emergency management Health aspects Hemagglutination Inhibition Tests Humans Immunization Influenza Influenza A virus - immunology Influenza A Virus, H1N1 Subtype - immunology Influenza A Virus, H2N2 Subtype - immunology Influenza A Virus, H3N2 Subtype - immunology Influenza in Birds - virology Influenza vaccines Influenza Vaccines - administration & dosage Influenza Vaccines - immunology Influenza, Human - prevention & control Influenza, Human - virology Methods Middle Aged Opinion Pandemics Prevention Public health Vaccines Virology Virology/Immune Evasion Virology/Vaccines |
title | Pandemic vaccine preparedness--have we left something behind? |
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