IL-10 signaling blockade controls murine West Nile virus infection

West Nile virus (WNV), a mosquito-borne single-stranded RNA flavivirus, can cause significant human morbidity and mortality. Our data show that interleukin-10 (IL-10) is dramatically elevated both in vitro and in vivo following WNV infection. Consistent with an etiologic role of IL-10 in WNV pathoge...

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Veröffentlicht in:	PLoS pathogens 2009-10, Vol.5 (10), p.e1000610-e1000610
Hauptverfasser:	Bai, Fengwei, Town, Terrence, Qian, Feng, Wang, Penghua, Kamanaka, Masahito, Connolly, Tarah M, Gate, David, Montgomery, Ruth R, Flavell, Richard A, Fikrig, Erol
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Care and treatment Cellular signal transduction Culicidae - virology Cytokines - antagonists & inhibitors Flavivirus Gene Expression Regulation Health aspects Humans Immune system Immunology/Immunity to Infections Infections Interleukin-10 Interleukin-10 - deficiency Interleukin-10 - genetics Interleukin-10 - physiology Macrophages, Peritoneal - immunology Mice Mice, Inbred C57BL Risk factors Signal Transduction Survivors Viral infections Viral Vaccines Virology/Effects of Virus Infection on Host Gene Expression Virology/Host Antiviral Responses Virology/New Therapies, including Antivirals and Immunotherapy West Nile fever West Nile Fever - immunology West Nile Fever - mortality West Nile Fever - prevention & control West Nile virus West Nile virus - pathogenicity
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