Association between selected oral pathogens and gastric precancerous lesions
We examined whether colonization of selected oral pathogens is associated with gastric precancerous lesions in a cross-sectional study. A total of 119 participants were included, of which 37 were cases of chronic atrophic gastritis, intestinal metaplasia, or dysplasia. An oral examination was perfor...
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| creator | Salazar, Christian R Sun, Jinghua Li, Yihong Francois, Fritz Corby, Patricia Perez-Perez, Guillermo Dasanayake, Ananda Pei, Zhiheng Chen, Yu |
| description | We examined whether colonization of selected oral pathogens is associated with gastric precancerous lesions in a cross-sectional study. A total of 119 participants were included, of which 37 were cases of chronic atrophic gastritis, intestinal metaplasia, or dysplasia. An oral examination was performed to measure periodontal indices. Plaque and saliva samples were tested with real-time quantitative PCR for DNA levels of pathogens related to periodontal disease (Porphyromonas gingivalis, Tannerella forsythensis, Treponema denticola, Actinobacillus actinomycetemcomitans) and dental caries (Streptococcus mutans and S. sobrinus). There were no consistent associations between DNA levels of selected bacterial species and gastric precancerous lesions, although an elevated but non-significant odds ratio (OR) for gastric precancerous lesions was observed in relation to increasing colonization of A. actinomycetemcomitans (OR = 1.36 for one standard deviation increase, 95% Confidence Interval = 0.87-2.12), P. gingivalis (OR = 1.12, 0.67-1.88) and T. denticola (OR = 1.34, 0.83-2.12) measured in plaque. To assess the influence of specific long-term infection, stratified analyses by levels of periodontal indices were conducted. A. actinomycetemcomitans was significantly associated with gastric precancerous lesions (OR = 2.51, 1.13-5.56) among those with ≥ median of percent tooth sites with PD ≥ 3 mm, compared with no association among those below the median (OR = 0.86, 0.43-1.72). A significantly stronger relationship was observed between the cumulative bacterial burden score of periodontal disease-related pathogens and gastric precancerous lesions among those with higher versus lower levels of periodontal disease indices (p-values for interactions: 0.03-0.06). Among individuals with periodontal disease, high levels of colonization of periodontal pathogens are associated with an increased risk of gastric precancerous lesions. |
| doi_str_mv | 10.1371/journal.pone.0051604 |
| format | Article |
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A total of 119 participants were included, of which 37 were cases of chronic atrophic gastritis, intestinal metaplasia, or dysplasia. An oral examination was performed to measure periodontal indices. Plaque and saliva samples were tested with real-time quantitative PCR for DNA levels of pathogens related to periodontal disease (Porphyromonas gingivalis, Tannerella forsythensis, Treponema denticola, Actinobacillus actinomycetemcomitans) and dental caries (Streptococcus mutans and S. sobrinus). There were no consistent associations between DNA levels of selected bacterial species and gastric precancerous lesions, although an elevated but non-significant odds ratio (OR) for gastric precancerous lesions was observed in relation to increasing colonization of A. actinomycetemcomitans (OR = 1.36 for one standard deviation increase, 95% Confidence Interval = 0.87-2.12), P. gingivalis (OR = 1.12, 0.67-1.88) and T. denticola (OR = 1.34, 0.83-2.12) measured in plaque. To assess the influence of specific long-term infection, stratified analyses by levels of periodontal indices were conducted. A. actinomycetemcomitans was significantly associated with gastric precancerous lesions (OR = 2.51, 1.13-5.56) among those with ≥ median of percent tooth sites with PD ≥ 3 mm, compared with no association among those below the median (OR = 0.86, 0.43-1.72). A significantly stronger relationship was observed between the cumulative bacterial burden score of periodontal disease-related pathogens and gastric precancerous lesions among those with higher versus lower levels of periodontal disease indices (p-values for interactions: 0.03-0.06). Among individuals with periodontal disease, high levels of colonization of periodontal pathogens are associated with an increased risk of gastric precancerous lesions.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0051604</identifier><identifier>PMID: 23308100</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Aged ; Aggregatibacter actinomycetemcomitans ; Analysis ; Bacteria ; Biology ; Colonization ; Confidence intervals ; Cross-Sectional Studies ; Dental caries ; Dental Caries - complications ; Dental Caries - microbiology ; Dental Plaque - complications ; Dental Plaque - microbiology ; Dentistry ; Deoxyribonucleic acid ; Disease ; DNA ; DNA, Bacterial - isolation & purification ; Dysplasia ; Epidemiology ; Female ; Gastric cancer ; Gastritis ; Gum disease ; Health promotion ; Health risks ; Helicobacter pylori ; Humans ; Infections ; Intestine ; Lesions ; Male ; Medical research ; Medicine ; Metaplasia ; Microbiota ; Middle Aged ; Pathogenic microorganisms ; Pathogens ; Periodontal disease ; Periodontal Diseases - complications ; Periodontal Diseases - microbiology ; Periodontal Index ; Periodontics ; Porphyromonas gingivalis ; Precancerous Conditions - etiology ; Precancerous Conditions - microbiology ; Precancerous Conditions - pathology ; Risk Factors ; Saliva ; Saliva - microbiology ; Stomach - microbiology ; Stomach - pathology ; Stomach cancer ; Stomach Neoplasms - etiology ; Stomach Neoplasms - microbiology ; Stomach Neoplasms - pathology ; Streptococcus mutans ; Studies ; Teeth ; Vitamin C</subject><ispartof>PloS one, 2013-01, Vol.8 (1), p.e51604-e51604</ispartof><rights>COPYRIGHT 2013 Public Library of Science</rights><rights>2013 Salazar et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2013 Salazar et al 2013 Salazar et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-e7eac5f1e8a6c685757d153a74f6ad642d1a6903bb5bcd35dd767c7f04ce29f03</citedby><cites>FETCH-LOGICAL-c692t-e7eac5f1e8a6c685757d153a74f6ad642d1a6903bb5bcd35dd767c7f04ce29f03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538744/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538744/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,861,882,2096,2915,23847,27905,27906,53772,53774,79349,79350</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23308100$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Shi, Songtao</contributor><creatorcontrib>Salazar, Christian R</creatorcontrib><creatorcontrib>Sun, Jinghua</creatorcontrib><creatorcontrib>Li, Yihong</creatorcontrib><creatorcontrib>Francois, Fritz</creatorcontrib><creatorcontrib>Corby, Patricia</creatorcontrib><creatorcontrib>Perez-Perez, Guillermo</creatorcontrib><creatorcontrib>Dasanayake, Ananda</creatorcontrib><creatorcontrib>Pei, Zhiheng</creatorcontrib><creatorcontrib>Chen, Yu</creatorcontrib><title>Association between selected oral pathogens and gastric precancerous lesions</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>We examined whether colonization of selected oral pathogens is associated with gastric precancerous lesions in a cross-sectional study. A total of 119 participants were included, of which 37 were cases of chronic atrophic gastritis, intestinal metaplasia, or dysplasia. An oral examination was performed to measure periodontal indices. Plaque and saliva samples were tested with real-time quantitative PCR for DNA levels of pathogens related to periodontal disease (Porphyromonas gingivalis, Tannerella forsythensis, Treponema denticola, Actinobacillus actinomycetemcomitans) and dental caries (Streptococcus mutans and S. sobrinus). There were no consistent associations between DNA levels of selected bacterial species and gastric precancerous lesions, although an elevated but non-significant odds ratio (OR) for gastric precancerous lesions was observed in relation to increasing colonization of A. actinomycetemcomitans (OR = 1.36 for one standard deviation increase, 95% Confidence Interval = 0.87-2.12), P. gingivalis (OR = 1.12, 0.67-1.88) and T. denticola (OR = 1.34, 0.83-2.12) measured in plaque. 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Among individuals with periodontal disease, high levels of colonization of periodontal pathogens are associated with an increased risk of gastric precancerous lesions.</description><subject>Aged</subject><subject>Aggregatibacter actinomycetemcomitans</subject><subject>Analysis</subject><subject>Bacteria</subject><subject>Biology</subject><subject>Colonization</subject><subject>Confidence intervals</subject><subject>Cross-Sectional Studies</subject><subject>Dental caries</subject><subject>Dental Caries - complications</subject><subject>Dental Caries - microbiology</subject><subject>Dental Plaque - complications</subject><subject>Dental Plaque - microbiology</subject><subject>Dentistry</subject><subject>Deoxyribonucleic acid</subject><subject>Disease</subject><subject>DNA</subject><subject>DNA, Bacterial - isolation & purification</subject><subject>Dysplasia</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Gastric cancer</subject><subject>Gastritis</subject><subject>Gum disease</subject><subject>Health promotion</subject><subject>Health risks</subject><subject>Helicobacter pylori</subject><subject>Humans</subject><subject>Infections</subject><subject>Intestine</subject><subject>Lesions</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Metaplasia</subject><subject>Microbiota</subject><subject>Middle Aged</subject><subject>Pathogenic microorganisms</subject><subject>Pathogens</subject><subject>Periodontal disease</subject><subject>Periodontal Diseases - complications</subject><subject>Periodontal Diseases - microbiology</subject><subject>Periodontal Index</subject><subject>Periodontics</subject><subject>Porphyromonas gingivalis</subject><subject>Precancerous Conditions - etiology</subject><subject>Precancerous Conditions - microbiology</subject><subject>Precancerous Conditions - pathology</subject><subject>Risk Factors</subject><subject>Saliva</subject><subject>Saliva - microbiology</subject><subject>Stomach - microbiology</subject><subject>Stomach - pathology</subject><subject>Stomach cancer</subject><subject>Stomach Neoplasms - etiology</subject><subject>Stomach Neoplasms - microbiology</subject><subject>Stomach Neoplasms - pathology</subject><subject>Streptococcus mutans</subject><subject>Studies</subject><subject>Teeth</subject><subject>Vitamin C</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNkl2L1DAYhYso7jr6D0QLgujFjEnTJO2NMCx-DAws-HUb3iZvOx06TU1SP_69Gae7TGUvJBcN6XNOkpOTJE8pWVEm6Zu9HV0P3WqwPa4I4VSQ_F5ySUuWLUVG2P2z-UXyyPt9hFghxMPkImOMFJSQy2S79t7qFkJr-7TC8BOxTz12qAOa1Dro0gHCzjbY-xR6kzbgg2t1OjjU0Gt0dvRphz7q_ePkQQ2dxyfTd5F8ff_uy9XH5fb6w-ZqvV1qUWZhiRJB85piAUKLgksuDeUMZF4LMCLPDAVRElZVvNKGcWOkkFrWJNeYlTVhi-T5yXforFdTEF7RrCgJzzJSRmJzIoyFvRpcewD3W1lo1d8F6xoFLrS6Q8W1qCEDkILRvKZVWQhueJWVgEIXjEavt9NuY3VAo7EPMZaZ6fxP3-5UY38oFuOWeR4NXk0Gzn4f0Qd1aL3GroMeY3rx3JLljFNWRPTFP-jdt5uoBuIF2r62cV99NFXrXBY5oTS-8CJZ3UHFYfDQ6tiauo3rM8HrmSAyAX-FBkbv1ebzp_9nr7_N2Zdn7A6hCztvu_HYOT8H8xOonfXeYX0bMiXqWPqbNNSx9GoqfZQ9O3-gW9FNy9kf5n38bA</recordid><startdate>20130107</startdate><enddate>20130107</enddate><creator>Salazar, Christian R</creator><creator>Sun, Jinghua</creator><creator>Li, Yihong</creator><creator>Francois, Fritz</creator><creator>Corby, Patricia</creator><creator>Perez-Perez, Guillermo</creator><creator>Dasanayake, Ananda</creator><creator>Pei, Zhiheng</creator><creator>Chen, Yu</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20130107</creationdate><title>Association between selected oral pathogens and gastric precancerous lesions</title><author>Salazar, Christian R ; Sun, Jinghua ; Li, Yihong ; Francois, Fritz ; Corby, Patricia ; Perez-Perez, Guillermo ; Dasanayake, Ananda ; Pei, Zhiheng ; Chen, Yu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-e7eac5f1e8a6c685757d153a74f6ad642d1a6903bb5bcd35dd767c7f04ce29f03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Aged</topic><topic>Aggregatibacter actinomycetemcomitans</topic><topic>Analysis</topic><topic>Bacteria</topic><topic>Biology</topic><topic>Colonization</topic><topic>Confidence intervals</topic><topic>Cross-Sectional Studies</topic><topic>Dental caries</topic><topic>Dental Caries - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Salazar, Christian R</au><au>Sun, Jinghua</au><au>Li, Yihong</au><au>Francois, Fritz</au><au>Corby, Patricia</au><au>Perez-Perez, Guillermo</au><au>Dasanayake, Ananda</au><au>Pei, Zhiheng</au><au>Chen, Yu</au><au>Shi, Songtao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between selected oral pathogens and gastric precancerous lesions</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2013-01-07</date><risdate>2013</risdate><volume>8</volume><issue>1</issue><spage>e51604</spage><epage>e51604</epage><pages>e51604-e51604</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>We examined whether colonization of selected oral pathogens is associated with gastric precancerous lesions in a cross-sectional study. A total of 119 participants were included, of which 37 were cases of chronic atrophic gastritis, intestinal metaplasia, or dysplasia. An oral examination was performed to measure periodontal indices. Plaque and saliva samples were tested with real-time quantitative PCR for DNA levels of pathogens related to periodontal disease (Porphyromonas gingivalis, Tannerella forsythensis, Treponema denticola, Actinobacillus actinomycetemcomitans) and dental caries (Streptococcus mutans and S. sobrinus). There were no consistent associations between DNA levels of selected bacterial species and gastric precancerous lesions, although an elevated but non-significant odds ratio (OR) for gastric precancerous lesions was observed in relation to increasing colonization of A. actinomycetemcomitans (OR = 1.36 for one standard deviation increase, 95% Confidence Interval = 0.87-2.12), P. gingivalis (OR = 1.12, 0.67-1.88) and T. denticola (OR = 1.34, 0.83-2.12) measured in plaque. To assess the influence of specific long-term infection, stratified analyses by levels of periodontal indices were conducted. A. actinomycetemcomitans was significantly associated with gastric precancerous lesions (OR = 2.51, 1.13-5.56) among those with ≥ median of percent tooth sites with PD ≥ 3 mm, compared with no association among those below the median (OR = 0.86, 0.43-1.72). A significantly stronger relationship was observed between the cumulative bacterial burden score of periodontal disease-related pathogens and gastric precancerous lesions among those with higher versus lower levels of periodontal disease indices (p-values for interactions: 0.03-0.06). Among individuals with periodontal disease, high levels of colonization of periodontal pathogens are associated with an increased risk of gastric precancerous lesions.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23308100</pmid><doi>10.1371/journal.pone.0051604</doi><tpages>e51604</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2013-01, Vol.8 (1), p.e51604-e51604 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1289052209 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS); EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Aged Aggregatibacter actinomycetemcomitans Analysis Bacteria Biology Colonization Confidence intervals Cross-Sectional Studies Dental caries Dental Caries - complications Dental Caries - microbiology Dental Plaque - complications Dental Plaque - microbiology Dentistry Deoxyribonucleic acid Disease DNA DNA, Bacterial - isolation & purification Dysplasia Epidemiology Female Gastric cancer Gastritis Gum disease Health promotion Health risks Helicobacter pylori Humans Infections Intestine Lesions Male Medical research Medicine Metaplasia Microbiota Middle Aged Pathogenic microorganisms Pathogens Periodontal disease Periodontal Diseases - complications Periodontal Diseases - microbiology Periodontal Index Periodontics Porphyromonas gingivalis Precancerous Conditions - etiology Precancerous Conditions - microbiology Precancerous Conditions - pathology Risk Factors Saliva Saliva - microbiology Stomach - microbiology Stomach - pathology Stomach cancer Stomach Neoplasms - etiology Stomach Neoplasms - microbiology Stomach Neoplasms - pathology Streptococcus mutans Studies Teeth Vitamin C |
| title | Association between selected oral pathogens and gastric precancerous lesions |
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