Plasmodium falciparum heterochromatin protein 1 marks genomic loci linked to phenotypic variation of exported virulence factors

Epigenetic processes are the main conductors of phenotypic variation in eukaryotes. The malaria parasite Plasmodium falciparum employs antigenic variation of the major surface antigen PfEMP1, encoded by 60 var genes, to evade acquired immune responses. Antigenic variation of PfEMP1 occurs through in...

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Veröffentlicht in:	PLoS pathogens 2009-09, Vol.5 (9), p.e1000569-1000569
Hauptverfasser:	Flueck, Christian, Bartfai, Richard, Volz, Jennifer, Niederwieser, Igor, Salcedo-Amaya, Adriana M, Alako, Blaise T F, Ehlgen, Florian, Ralph, Stuart A, Cowman, Alan F, Bozdech, Zbynek, Stunnenberg, Hendrik G, Voss, Till S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Biology/Gene Expression Cell Biology/Nuclear Structure and Function Cell Nucleus - metabolism Centromere - metabolism Chromosomal Proteins, Non-Histone - genetics Chromosomal Proteins, Non-Histone - metabolism Chromosomes Erythrocytes Gene loci Gene Silencing Genetics and Genomics/Bioinformatics Genetics and Genomics/Chromosome Biology Genetics and Genomics/Epigenetics Genetics and Genomics/Gene Expression Genetics and Genomics/Nuclear Structure and Function Genome, Protozoan Genomics Infectious Diseases/Protozoal Infections Malaria Molecular Biology/Centromeres Molecular Biology/Chromatin Structure Molecular Biology/Histone Modification Multigene Family Oligonucleotide Array Sequence Analysis Parasites Phenotype Plasmodium falciparum Plasmodium falciparum - genetics Plasmodium falciparum - pathogenicity Proteins Protozoan Proteins - genetics Protozoan Proteins - metabolism Reproducibility of Results Virulence Factors - genetics Virulence Factors - metabolism
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