The effect of Trim5 polymorphisms on the clinical course of HIV-1 infection

The antiviral factor tripartite interaction motif 5alpha (Trim5alpha) restricts a broad range of retroviruses in a species-specific manner. Although human Trim5alpha is unable to block HIV-1 infection in human cells, a modest inhibition of HIV-1 replication has been reported. Recently two polymorphi...

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Veröffentlicht in:	PLoS pathogens 2008-02, Vol.4 (2), p.e18-e18
Hauptverfasser:	van Manen, Daniëlle, Rits, Maarten A N, Beugeling, Corrine, van Dort, Karel, Schuitemaker, Hanneke, Kootstra, Neeltje A
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome AIDS Carrier Proteins - genetics Carrier Proteins - metabolism Cohort Studies Disease control Disease Progression Genes Genetic Predisposition to Disease Genotype HIV HIV Infections - genetics HIV Infections - mortality HIV Infections - virology HIV Seropositivity - epidemiology HIV-1 - growth & development HIV-1 - pathogenicity Homo (Human) Homosexuality Homozygote Human immunodeficiency virus Humans Infectious Diseases Netherlands - epidemiology Polymorphism, Single Nucleotide Receptors, CXCR4 - genetics Receptors, CXCR4 - metabolism RNA, Viral - genetics Survival Rate Viral Load Virology Viruses
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