The interferon response inhibits HIV particle production by induction of TRIM22

Treatment of human cells with Type 1 interferons restricts HIV replication. Here we report that the tripartite motif protein TRIM22 is a key mediator. We used transcriptional profiling to identify cellular genes that were induced by interferon treatment and identified TRIM22 as one of the most stron...

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Veröffentlicht in:	PLoS pathogens 2008-02, Vol.4 (2), p.e1000007-e1000007
Hauptverfasser:	Barr, Stephen D, Smiley, James R, Bushman, Frederic D
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiviral Agents - pharmacology Cell Line Cell Membrane DNA Mutational Analysis Gene Expression Regulation, Viral - drug effects Gene Products, gag - genetics Gene Products, gag - metabolism Gene Silencing Genetic aspects Genetic transcription Health aspects HIV (Viruses) HIV-1 - drug effects HIV-1 - metabolism Human immunodeficiency virus 1 Human Immunodeficiency Virus Proteins - metabolism Humans Immunology/Immune Response Immunology/Immunity to Infections Immunology/Innate Immunity Infectious Diseases/HIV Infection and AIDS Interferon Interferon Type I - pharmacology Medical research Minor Histocompatibility Antigens Oligonucleotide Array Sequence Analysis Physiological aspects Proteins Repressor Proteins - genetics Repressor Proteins - metabolism RNA, Small Interfering - genetics Signal transduction Transcription Factors - genetics Transcription Factors - metabolism Transfection Tripartite Motif Proteins Up-Regulation Virion - drug effects Virion - metabolism Virology/Host Antiviral Responses Virology/Immunodeficiency Viruses Virology/Mechanisms of Resistance and Susceptibility, including Host Genetics Virology/Viral and Gene Regulation Virology/Virion Structure, Assembly, and Egress Virus Replication - drug effects Viruses
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