Mucosal damage and neutropenia are required for Candida albicans dissemination

Candida albicans fungemia in cancer patients is thought to develop from initial gastrointestinal (GI) colonization with subsequent translocation into the bloodstream after administration of chemotherapy. It is unclear what components of the innate immune system are necessary for preventing C. albica...

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Veröffentlicht in:	PLoS pathogens 2008-02, Vol.4 (2), p.e35
Hauptverfasser:	Koh, Andrew Y, Köhler, Julia R, Coggshall, Kathleen T, Van Rooijen, Nico, Pier, Gerald B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - pharmacology Bacterial Translocation - drug effects Cancer Cancer therapies Candida albicans - drug effects Candida albicans - pathogenicity Candidiasis - drug therapy Candidiasis - immunology Candidiasis - microbiology Chemotherapy Cyclophosphamide - therapeutic use Disease Models, Animal Experiments Female Fungal infections Fungi Gastrointestinal Tract - microbiology Gastrointestinal Tract - pathology Gene Silencing Homo (human) Immunology Immunosuppression Therapy Infectious Diseases Liver Longevity - drug effects Mice Mice, Inbred C3H Mice, Knockout Mortality Mucous Membrane - drug effects Mucous Membrane - microbiology Mucous Membrane - pathology Mus (mouse) Neutropenia - chemically induced Neutropenia - microbiology Neutropenia - pathology Oncology Spleen Yeast and Fungi
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