Human african trypanosomiasis diagnosis in first-line health services of endemic countries, a systematic review
While the incidence of Human African Trypanosomiasis (HAT) is decreasing, the control approach is shifting from active population screening by mobile teams to passive case detection in primary care centers. We conducted a systematic review of the literature between 1970 and 2011 to assess which diag...
Gespeichert in:
| Veröffentlicht in: | PLoS neglected tropical diseases 2012-11, Vol.6 (11), p.e1919-e1919 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e1919 |
|---|---|
| container_issue | 11 |
| container_start_page | e1919 |
| container_title | PLoS neglected tropical diseases |
| container_volume | 6 |
| creator | Mitashi, Patrick Hasker, Epco Lejon, Veerle Kande, Victor Muyembe, Jean-Jacques Lutumba, Pascal Boelaert, Marleen |
| description | While the incidence of Human African Trypanosomiasis (HAT) is decreasing, the control approach is shifting from active population screening by mobile teams to passive case detection in primary care centers. We conducted a systematic review of the literature between 1970 and 2011 to assess which diagnostic tools are most suitable for use in first-line health facilities in endemic countries. Our search retrieved 16 different screening and confirmation tests for HAT. The thermostable format of the Card Agglutination Test for Trypanosomiasis (CATT test) was the most appropriate screening test. Lateral flow antibody detection tests could become alternative screening tests in the near future. Confirmation of HAT diagnosis still depends on visualizing the parasite in direct microscopy. All other currently available confirmation tests are either technically too demanding and/or lack sensitivity and thus rather inappropriate for use at health center level. Novel applications of molecular tests may have potential for use at district hospital level. |
| doi_str_mv | 10.1371/journal.pntd.0001919 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1288114124</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A311851597</galeid><doaj_id>oai_doaj_org_article_667dbc9b40f64741ae5c4e437340547d</doaj_id><sourcerecordid>A311851597</sourcerecordid><originalsourceid>FETCH-LOGICAL-c596t-2ba14cce16ccf1923e845cfbd7a13c010020803201afa2bc42da61b70a48c1d03</originalsourceid><addsrcrecordid>eNptkk1vEzEQhlcIREvgHyBYCQn1QILHH_txQaoqaCtV4gJna9Y7mzjatYO9G5R_j9OkVSJhH2yPn3k9M54sew9sAaKEr2s_BYf9YuPGdsEYgxrqF9kl1ELNeSnUy5P9RfYmxjVjqlYVvM4uuOCsrgp2mfm7aUCXYxesSesYdht0PvrBYrQxby0u0zHtrMs7G-I4762jfEXYj6s8UthaQzH3XU6upcGa3PjJjcFS_JJjHndxpAHHZA-0tfT3bfaqwz7Su-M6y37_-P7r5m7-8PP2_ub6YW5UXYxz3iBIYwgKYzqouaBKKtM1bYkgDAPGOKtYygKwQ94YyVssoCkZyspAy8Qs-3jQ3fQ-6mOtogZeVQASuEzE_YFoPa71JtgBw057tPrR4MNSY0iB96SLomwbUzeSdYUsJSApI0mKUkimZNkmrW_H16ZmoNZQqgD2Z6LnN86u9NJvtVAplZTeLLs6CgT_Z6I46sFGQ32Pjvy0jzsNwWVdJPTTAV1iCs26zidFs8f1tQCoFKi6TNTiP1Saj5_kHXU22c8cPp84HP43-n4arXfxHJQH0AQfY6DuOU1get-ZT9XW-87Ux85Mbh9OS_Ts9NSK4h8XH-HU</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1222232496</pqid></control><display><type>article</type><title>Human african trypanosomiasis diagnosis in first-line health services of endemic countries, a systematic review</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>PubMed Central Open Access</source><source>Public Library of Science (PLoS)</source><creator>Mitashi, Patrick ; Hasker, Epco ; Lejon, Veerle ; Kande, Victor ; Muyembe, Jean-Jacques ; Lutumba, Pascal ; Boelaert, Marleen</creator><contributor>Ghedin, Elodie</contributor><creatorcontrib>Mitashi, Patrick ; Hasker, Epco ; Lejon, Veerle ; Kande, Victor ; Muyembe, Jean-Jacques ; Lutumba, Pascal ; Boelaert, Marleen ; Ghedin, Elodie</creatorcontrib><description>While the incidence of Human African Trypanosomiasis (HAT) is decreasing, the control approach is shifting from active population screening by mobile teams to passive case detection in primary care centers. We conducted a systematic review of the literature between 1970 and 2011 to assess which diagnostic tools are most suitable for use in first-line health facilities in endemic countries. Our search retrieved 16 different screening and confirmation tests for HAT. The thermostable format of the Card Agglutination Test for Trypanosomiasis (CATT test) was the most appropriate screening test. Lateral flow antibody detection tests could become alternative screening tests in the near future. Confirmation of HAT diagnosis still depends on visualizing the parasite in direct microscopy. All other currently available confirmation tests are either technically too demanding and/or lack sensitivity and thus rather inappropriate for use at health center level. Novel applications of molecular tests may have potential for use at district hospital level.</description><identifier>ISSN: 1935-2735</identifier><identifier>ISSN: 1935-2727</identifier><identifier>EISSN: 1935-2735</identifier><identifier>DOI: 10.1371/journal.pntd.0001919</identifier><identifier>PMID: 23209860</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>African trypanosomiasis ; Blood ; Care and treatment ; Diagnosis ; Diagnostic services ; Diagnostic Tests, Routine - methods ; Endemic Diseases ; Forecasts and trends ; Humans ; Management ; Medical examination ; Medicine ; Methods ; Parasitology - methods ; Polymerase chain reaction ; Trypanosomiasis, African - diagnosis ; Trypanosomiasis, African - epidemiology</subject><ispartof>PLoS neglected tropical diseases, 2012-11, Vol.6 (11), p.e1919-e1919</ispartof><rights>COPYRIGHT 2012 Public Library of Science</rights><rights>2012 Mitashi et al 2012 Mitashi et al</rights><rights>2012 Mitashi et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Mitashi P, Hasker E, Lejon V, Kande V, Muyembe J-J, et al. (2012) Human African Trypanosomiasis Diagnosis in First-Line Health Services of Endemic Countries, a Systematic Review. PLoS Negl Trop Dis 6(11): e1919. doi:10.1371/journal.pntd.0001919</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c596t-2ba14cce16ccf1923e845cfbd7a13c010020803201afa2bc42da61b70a48c1d03</citedby><cites>FETCH-LOGICAL-c596t-2ba14cce16ccf1923e845cfbd7a13c010020803201afa2bc42da61b70a48c1d03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510092/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510092/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23209860$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Ghedin, Elodie</contributor><creatorcontrib>Mitashi, Patrick</creatorcontrib><creatorcontrib>Hasker, Epco</creatorcontrib><creatorcontrib>Lejon, Veerle</creatorcontrib><creatorcontrib>Kande, Victor</creatorcontrib><creatorcontrib>Muyembe, Jean-Jacques</creatorcontrib><creatorcontrib>Lutumba, Pascal</creatorcontrib><creatorcontrib>Boelaert, Marleen</creatorcontrib><title>Human african trypanosomiasis diagnosis in first-line health services of endemic countries, a systematic review</title><title>PLoS neglected tropical diseases</title><addtitle>PLoS Negl Trop Dis</addtitle><description>While the incidence of Human African Trypanosomiasis (HAT) is decreasing, the control approach is shifting from active population screening by mobile teams to passive case detection in primary care centers. We conducted a systematic review of the literature between 1970 and 2011 to assess which diagnostic tools are most suitable for use in first-line health facilities in endemic countries. Our search retrieved 16 different screening and confirmation tests for HAT. The thermostable format of the Card Agglutination Test for Trypanosomiasis (CATT test) was the most appropriate screening test. Lateral flow antibody detection tests could become alternative screening tests in the near future. Confirmation of HAT diagnosis still depends on visualizing the parasite in direct microscopy. All other currently available confirmation tests are either technically too demanding and/or lack sensitivity and thus rather inappropriate for use at health center level. Novel applications of molecular tests may have potential for use at district hospital level.</description><subject>African trypanosomiasis</subject><subject>Blood</subject><subject>Care and treatment</subject><subject>Diagnosis</subject><subject>Diagnostic services</subject><subject>Diagnostic Tests, Routine - methods</subject><subject>Endemic Diseases</subject><subject>Forecasts and trends</subject><subject>Humans</subject><subject>Management</subject><subject>Medical examination</subject><subject>Medicine</subject><subject>Methods</subject><subject>Parasitology - methods</subject><subject>Polymerase chain reaction</subject><subject>Trypanosomiasis, African - diagnosis</subject><subject>Trypanosomiasis, African - epidemiology</subject><issn>1935-2735</issn><issn>1935-2727</issn><issn>1935-2735</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>DOA</sourceid><recordid>eNptkk1vEzEQhlcIREvgHyBYCQn1QILHH_txQaoqaCtV4gJna9Y7mzjatYO9G5R_j9OkVSJhH2yPn3k9M54sew9sAaKEr2s_BYf9YuPGdsEYgxrqF9kl1ELNeSnUy5P9RfYmxjVjqlYVvM4uuOCsrgp2mfm7aUCXYxesSesYdht0PvrBYrQxby0u0zHtrMs7G-I4762jfEXYj6s8UthaQzH3XU6upcGa3PjJjcFS_JJjHndxpAHHZA-0tfT3bfaqwz7Su-M6y37_-P7r5m7-8PP2_ub6YW5UXYxz3iBIYwgKYzqouaBKKtM1bYkgDAPGOKtYygKwQ94YyVssoCkZyspAy8Qs-3jQ3fQ-6mOtogZeVQASuEzE_YFoPa71JtgBw057tPrR4MNSY0iB96SLomwbUzeSdYUsJSApI0mKUkimZNkmrW_H16ZmoNZQqgD2Z6LnN86u9NJvtVAplZTeLLs6CgT_Z6I46sFGQ32Pjvy0jzsNwWVdJPTTAV1iCs26zidFs8f1tQCoFKi6TNTiP1Saj5_kHXU22c8cPp84HP43-n4arXfxHJQH0AQfY6DuOU1get-ZT9XW-87Ux85Mbh9OS_Ts9NSK4h8XH-HU</recordid><startdate>20121101</startdate><enddate>20121101</enddate><creator>Mitashi, Patrick</creator><creator>Hasker, Epco</creator><creator>Lejon, Veerle</creator><creator>Kande, Victor</creator><creator>Muyembe, Jean-Jacques</creator><creator>Lutumba, Pascal</creator><creator>Boelaert, Marleen</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20121101</creationdate><title>Human african trypanosomiasis diagnosis in first-line health services of endemic countries, a systematic review</title><author>Mitashi, Patrick ; Hasker, Epco ; Lejon, Veerle ; Kande, Victor ; Muyembe, Jean-Jacques ; Lutumba, Pascal ; Boelaert, Marleen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c596t-2ba14cce16ccf1923e845cfbd7a13c010020803201afa2bc42da61b70a48c1d03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>African trypanosomiasis</topic><topic>Blood</topic><topic>Care and treatment</topic><topic>Diagnosis</topic><topic>Diagnostic services</topic><topic>Diagnostic Tests, Routine - methods</topic><topic>Endemic Diseases</topic><topic>Forecasts and trends</topic><topic>Humans</topic><topic>Management</topic><topic>Medical examination</topic><topic>Medicine</topic><topic>Methods</topic><topic>Parasitology - methods</topic><topic>Polymerase chain reaction</topic><topic>Trypanosomiasis, African - diagnosis</topic><topic>Trypanosomiasis, African - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mitashi, Patrick</creatorcontrib><creatorcontrib>Hasker, Epco</creatorcontrib><creatorcontrib>Lejon, Veerle</creatorcontrib><creatorcontrib>Kande, Victor</creatorcontrib><creatorcontrib>Muyembe, Jean-Jacques</creatorcontrib><creatorcontrib>Lutumba, Pascal</creatorcontrib><creatorcontrib>Boelaert, Marleen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PLoS neglected tropical diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mitashi, Patrick</au><au>Hasker, Epco</au><au>Lejon, Veerle</au><au>Kande, Victor</au><au>Muyembe, Jean-Jacques</au><au>Lutumba, Pascal</au><au>Boelaert, Marleen</au><au>Ghedin, Elodie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Human african trypanosomiasis diagnosis in first-line health services of endemic countries, a systematic review</atitle><jtitle>PLoS neglected tropical diseases</jtitle><addtitle>PLoS Negl Trop Dis</addtitle><date>2012-11-01</date><risdate>2012</risdate><volume>6</volume><issue>11</issue><spage>e1919</spage><epage>e1919</epage><pages>e1919-e1919</pages><issn>1935-2735</issn><issn>1935-2727</issn><eissn>1935-2735</eissn><abstract>While the incidence of Human African Trypanosomiasis (HAT) is decreasing, the control approach is shifting from active population screening by mobile teams to passive case detection in primary care centers. We conducted a systematic review of the literature between 1970 and 2011 to assess which diagnostic tools are most suitable for use in first-line health facilities in endemic countries. Our search retrieved 16 different screening and confirmation tests for HAT. The thermostable format of the Card Agglutination Test for Trypanosomiasis (CATT test) was the most appropriate screening test. Lateral flow antibody detection tests could become alternative screening tests in the near future. Confirmation of HAT diagnosis still depends on visualizing the parasite in direct microscopy. All other currently available confirmation tests are either technically too demanding and/or lack sensitivity and thus rather inappropriate for use at health center level. Novel applications of molecular tests may have potential for use at district hospital level.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23209860</pmid><doi>10.1371/journal.pntd.0001919</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1935-2735 |
| ispartof | PLoS neglected tropical diseases, 2012-11, Vol.6 (11), p.e1919-e1919 |
| issn | 1935-2735 1935-2727 1935-2735 |
| language | eng |
| recordid | cdi_plos_journals_1288114124 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access; Public Library of Science (PLoS) |
| subjects | African trypanosomiasis Blood Care and treatment Diagnosis Diagnostic services Diagnostic Tests, Routine - methods Endemic Diseases Forecasts and trends Humans Management Medical examination Medicine Methods Parasitology - methods Polymerase chain reaction Trypanosomiasis, African - diagnosis Trypanosomiasis, African - epidemiology |
| title | Human african trypanosomiasis diagnosis in first-line health services of endemic countries, a systematic review |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T15%3A00%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Human%20african%20trypanosomiasis%20diagnosis%20in%20first-line%20health%20services%20of%20endemic%20countries,%20a%20systematic%20review&rft.jtitle=PLoS%20neglected%20tropical%20diseases&rft.au=Mitashi,%20Patrick&rft.date=2012-11-01&rft.volume=6&rft.issue=11&rft.spage=e1919&rft.epage=e1919&rft.pages=e1919-e1919&rft.issn=1935-2735&rft.eissn=1935-2735&rft_id=info:doi/10.1371/journal.pntd.0001919&rft_dat=%3Cgale_plos_%3EA311851597%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1222232496&rft_id=info:pmid/23209860&rft_galeid=A311851597&rft_doaj_id=oai_doaj_org_article_667dbc9b40f64741ae5c4e437340547d&rfr_iscdi=true |