RIG-I, MDA5 and TLR3 synergistically play an important role in restriction of dengue virus infection

Dengue virus (DV) infection is one of the most common mosquito-borne viral diseases in the world. The innate immune system is important for the early detection of virus and for mounting a cascade of defense measures which include the production of type 1 interferon (IFN). Hence, a thorough understan...

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Veröffentlicht in:	PLoS neglected tropical diseases 2011-01, Vol.5 (1), p.e926-e926
Hauptverfasser:	Nasirudeen, A M A, Wong, Hui Hui, Thien, Peiling, Xu, Shengli, Lam, Kong-Peng, Liu, Ding Xiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Cells, Cultured Cytokines DEAD Box Protein 58 DEAD-box RNA Helicases - immunology DEAD-box RNA Helicases - metabolism Dengue - immunology Dengue - pathology Dengue fever Dengue virus Dengue Virus - immunology Dengue Virus - pathogenicity Dengue virus type 1 Gene Silencing Genes Genetic engineering Hepatitis Hepatocytes - virology Humans Immune response Immune system Immunology/Cellular Microbiology and Pathogenesis Immunology/Immune Response Immunology/Immunity to Infections Immunology/Innate Immunity Infections Interferon Interferon-Induced Helicase, IFIH1 Interferons - immunology Interferons - metabolism Macrophages - virology Melanoma Mice Mice, Inbred C57BL Microbiology/Cellular Microbiology and Pathogenesis Microbiology/Innate Immunity Pattern recognition Receptors, Immunologic Reverse Transcriptase Polymerase Chain Reaction Sensors Toll-Like Receptor 3 - immunology Toll-Like Receptor 3 - metabolism Tropical diseases Vector-borne diseases Viral diseases Viral infections Viruses West Nile virus
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