Emergence of a globally dominant IncHI1 plasmid type associated with multiple drug resistant typhoid

Typhoid fever, caused by Salmonella enterica serovar Typhi (S. Typhi), remains a serious global health concern. Since their emergence in the mid-1970s multi-drug resistant (MDR) S. Typhi now dominate drug sensitive equivalents in many regions. MDR in S. Typhi is almost exclusively conferred by self-...

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Veröffentlicht in:	PLoS neglected tropical diseases 2011-07, Vol.5 (7), p.e1245-e1245
Hauptverfasser:	Holt, Kathryn E, Phan, Minh Duy, Baker, Stephen, Duy, Pham Thanh, Nga, Tran Vu Thieu, Nair, Satheesh, Turner, A Keith, Walsh, Ciara, Fanning, Séamus, Farrell-Ward, Sinéad, Dutta, Shanta, Kariuki, Sam, Weill, François-Xavier, Parkhill, Julian, Dougan, Gordon, Wain, John
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology Antimicrobial agents Bacteria Biology Care and treatment DNA, Bacterial - genetics DNA, Bacterial - isolation & purification Drug resistance Drug resistance in microorganisms Drug Resistance, Multiple, Bacterial - genetics Genetic aspects Global health Haplotypes Humans Life Sciences Medicine Microbial Sensitivity Tests Pharmaceutical sciences Pharmacology Phylogeny Plasmids Plasmids - genetics Polymorphism, Single Nucleotide Real-Time Polymerase Chain Reaction Retrospective Studies Risk factors Salmonella Salmonella typhi - drug effects Salmonella typhi - genetics Salmonella typhi - isolation & purification Santé publique et épidémiologie Sequence Analysis, DNA Single nucleotide polymorphisms Sodium chloride Tropical diseases Typhoid Typhoid fever Typhoid Fever - drug therapy Typhoid Fever - microbiology Waterborne diseases
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