First description of a cluster of acute/subacute paracoccidioidomycosis cases and its association with a climatic anomaly
Identifying clusters of acute paracoccidioidomycosis cases could potentially help in identifying the environmental factors that influence the incidence of this mycosis. However, unlike other endemic mycoses, there are no published reports of clusters of paracoccidioidomycosis. A retrospective cluste...
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| Veröffentlicht in: | PLoS neglected tropical diseases 2010-03, Vol.4 (3), p.e643-e643 |
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| creator | Barrozo, Ligia Vizeu Benard, Gil Silva, Maria Elisa Siqueira Bagagli, Eduardo Marques, Silvio Alencar Mendes, Rinaldo Poncio |
| description | Identifying clusters of acute paracoccidioidomycosis cases could potentially help in identifying the environmental factors that influence the incidence of this mycosis. However, unlike other endemic mycoses, there are no published reports of clusters of paracoccidioidomycosis.
A retrospective cluster detection test was applied to verify if an excess of acute form (AF) paracoccidioidomycosis cases in time and/or space occurred in Botucatu, an endemic area in São Paulo State. The scan-test SaTScan v7.0.3 was set to find clusters for the maximum temporal period of 1 year. The temporal test indicated a significant cluster in 1985 (P |
| doi_str_mv | 10.1371/journal.pntd.0000643 |
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A retrospective cluster detection test was applied to verify if an excess of acute form (AF) paracoccidioidomycosis cases in time and/or space occurred in Botucatu, an endemic area in São Paulo State. The scan-test SaTScan v7.0.3 was set to find clusters for the maximum temporal period of 1 year. The temporal test indicated a significant cluster in 1985 (P<0.005). This cluster comprised 10 cases, although 2.19 were expected for this year in this area. Age and clinical presentation of these cases were typical of AF paracccidioidomycosis. The space-time test confirmed the temporal cluster in 1985 and showed the localities where the risk was higher in that year. The cluster suggests that some particularities took place in the antecedent years in those localities. Analysis of climate variables showed that soil water storage was atypically high in 1982/83 ( approximately 2.11/2.5 SD above mean), and the absolute air humidity in 1984, the year preceding the cluster, was much higher than normal ( approximately 1.6 SD above mean), conditions that may have favored, respectively, antecedent fungal growth in the soil and conidia liberation in 1984, the probable year of exposure. These climatic anomalies in this area was due to the 1982/83 El Niño event, the strongest in the last 50 years.
We describe the first cluster of AF paracoccidioidomycosis, which was potentially linked to a climatic anomaly caused by the 1982/83 El Niño Southern Oscillation. This finding is important because it may help to clarify the conditions that favor Paracoccidioides brasiliensis survival and growth in the environment and that enhance human exposure, thus allowing the development of preventive measures.</description><identifier>ISSN: 1935-2735</identifier><identifier>ISSN: 1935-2727</identifier><identifier>EISSN: 1935-2735</identifier><identifier>DOI: 10.1371/journal.pntd.0000643</identifier><identifier>PMID: 20361032</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adolescent ; Adult ; Brazil - epidemiology ; Child ; Child, Preschool ; Climate ; Climate change ; Cluster Analysis ; Disease ; Disease prevention ; Ecology/Environmental Microbiology ; El Nino ; Environmental factors ; Female ; Fungal infections ; Humans ; Male ; Moisture content ; Paracoccidioides - isolation & purification ; Paracoccidioidomycosis - epidemiology ; Precipitation ; Retrospective Studies ; Soil water ; Southern Oscillation ; Studies ; Tropical diseases ; Water storage ; Young Adult</subject><ispartof>PLoS neglected tropical diseases, 2010-03, Vol.4 (3), p.e643-e643</ispartof><rights>2010 Barrozo et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Barrozo LV, Benard G, Silva MES, Bagagli E, Marques SA, et al. (2010) First Description of a Cluster of Acute/Subacute Paracoccidioidomycosis Cases and Its Association with a Climatic Anomaly. PLoS Negl Trop Dis 4(3): e643. doi:10.1371/journal.pntd.0000643</rights><rights>Barrozo et al. 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c525t-b0cc8de2999d3492c5b425bd5b987e40ec5c58c6bda78aec1e126b71adacca933</citedby><cites>FETCH-LOGICAL-c525t-b0cc8de2999d3492c5b425bd5b987e40ec5c58c6bda78aec1e126b71adacca933</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2846938/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2846938/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20361032$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Carvalho, Marilia Sá</contributor><creatorcontrib>Barrozo, Ligia Vizeu</creatorcontrib><creatorcontrib>Benard, Gil</creatorcontrib><creatorcontrib>Silva, Maria Elisa Siqueira</creatorcontrib><creatorcontrib>Bagagli, Eduardo</creatorcontrib><creatorcontrib>Marques, Silvio Alencar</creatorcontrib><creatorcontrib>Mendes, Rinaldo Poncio</creatorcontrib><title>First description of a cluster of acute/subacute paracoccidioidomycosis cases and its association with a climatic anomaly</title><title>PLoS neglected tropical diseases</title><addtitle>PLoS Negl Trop Dis</addtitle><description>Identifying clusters of acute paracoccidioidomycosis cases could potentially help in identifying the environmental factors that influence the incidence of this mycosis. However, unlike other endemic mycoses, there are no published reports of clusters of paracoccidioidomycosis.
A retrospective cluster detection test was applied to verify if an excess of acute form (AF) paracoccidioidomycosis cases in time and/or space occurred in Botucatu, an endemic area in São Paulo State. The scan-test SaTScan v7.0.3 was set to find clusters for the maximum temporal period of 1 year. The temporal test indicated a significant cluster in 1985 (P<0.005). This cluster comprised 10 cases, although 2.19 were expected for this year in this area. Age and clinical presentation of these cases were typical of AF paracccidioidomycosis. The space-time test confirmed the temporal cluster in 1985 and showed the localities where the risk was higher in that year. The cluster suggests that some particularities took place in the antecedent years in those localities. Analysis of climate variables showed that soil water storage was atypically high in 1982/83 ( approximately 2.11/2.5 SD above mean), and the absolute air humidity in 1984, the year preceding the cluster, was much higher than normal ( approximately 1.6 SD above mean), conditions that may have favored, respectively, antecedent fungal growth in the soil and conidia liberation in 1984, the probable year of exposure. These climatic anomalies in this area was due to the 1982/83 El Niño event, the strongest in the last 50 years.
We describe the first cluster of AF paracoccidioidomycosis, which was potentially linked to a climatic anomaly caused by the 1982/83 El Niño Southern Oscillation. This finding is important because it may help to clarify the conditions that favor Paracoccidioides brasiliensis survival and growth in the environment and that enhance human exposure, thus allowing the development of preventive measures.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Brazil - epidemiology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Climate</subject><subject>Climate change</subject><subject>Cluster Analysis</subject><subject>Disease</subject><subject>Disease prevention</subject><subject>Ecology/Environmental Microbiology</subject><subject>El Nino</subject><subject>Environmental factors</subject><subject>Female</subject><subject>Fungal infections</subject><subject>Humans</subject><subject>Male</subject><subject>Moisture content</subject><subject>Paracoccidioides - isolation & purification</subject><subject>Paracoccidioidomycosis - epidemiology</subject><subject>Precipitation</subject><subject>Retrospective Studies</subject><subject>Soil water</subject><subject>Southern Oscillation</subject><subject>Studies</subject><subject>Tropical diseases</subject><subject>Water storage</subject><subject>Young Adult</subject><issn>1935-2735</issn><issn>1935-2727</issn><issn>1935-2735</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNptkk1v1DAQhi0EomXhHyCIxIHTbv0RJ_YFCVUUKlXiAmfLHjutV0kcbAe0_x5vNq1ahC9jj995PGO9CL0leEdYSy72YY6j7nfTmO0Ol9XU7Bk6J5LxLW0Zf_5of4ZepbTHmEsuyEt0RjFrCGb0HB2ufEy5si5B9FP2YaxCV-kK-jllF5cDzNldpNksm2rSUUMA8NYHb8NwgJB8qkAnlyo92srnElMK4PXC--Pz3UL0Q0lA0YRB94fX6EWn--TerHGDfl59-XH5bXvz_ev15eebLXDK89ZgAGEdlVJaVksK3NSUG8uNFK2rsQMOXEBjrG6FdkAcoY1pibYaQEvGNuj9iTv1Ian115IiVAiCqRS0KK5PChv0Xk2x9BkPKmivlkSIt0rH0nnvlLSCu66R1GpWG1nLrsWcENtQTDAYUVif1tdmMzgLbsxR90-gT29Gf6duw29FRd1IdgR8XAEx_JpdymrwCVzf69GFOamWMc4aWbQb9OEf5f-Hq08qiCGl6LqHXghWRyPdV6mjkdRqpFL27vEcD0X3zmF_AQGsyfw</recordid><startdate>20100301</startdate><enddate>20100301</enddate><creator>Barrozo, Ligia Vizeu</creator><creator>Benard, Gil</creator><creator>Silva, Maria Elisa Siqueira</creator><creator>Bagagli, Eduardo</creator><creator>Marques, Silvio Alencar</creator><creator>Mendes, Rinaldo Poncio</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7SS</scope><scope>7T2</scope><scope>7T7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>F1W</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>H95</scope><scope>H97</scope><scope>K9.</scope><scope>L.G</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20100301</creationdate><title>First description of a cluster of acute/subacute paracoccidioidomycosis cases and its association with a climatic anomaly</title><author>Barrozo, Ligia Vizeu ; Benard, Gil ; Silva, Maria Elisa Siqueira ; Bagagli, Eduardo ; Marques, Silvio Alencar ; Mendes, Rinaldo Poncio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c525t-b0cc8de2999d3492c5b425bd5b987e40ec5c58c6bda78aec1e126b71adacca933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Brazil - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PLoS neglected tropical diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Barrozo, Ligia Vizeu</au><au>Benard, Gil</au><au>Silva, Maria Elisa Siqueira</au><au>Bagagli, Eduardo</au><au>Marques, Silvio Alencar</au><au>Mendes, Rinaldo Poncio</au><au>Carvalho, Marilia Sá</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>First description of a cluster of acute/subacute paracoccidioidomycosis cases and its association with a climatic anomaly</atitle><jtitle>PLoS neglected tropical diseases</jtitle><addtitle>PLoS Negl Trop Dis</addtitle><date>2010-03-01</date><risdate>2010</risdate><volume>4</volume><issue>3</issue><spage>e643</spage><epage>e643</epage><pages>e643-e643</pages><issn>1935-2735</issn><issn>1935-2727</issn><eissn>1935-2735</eissn><abstract>Identifying clusters of acute paracoccidioidomycosis cases could potentially help in identifying the environmental factors that influence the incidence of this mycosis. However, unlike other endemic mycoses, there are no published reports of clusters of paracoccidioidomycosis.
A retrospective cluster detection test was applied to verify if an excess of acute form (AF) paracoccidioidomycosis cases in time and/or space occurred in Botucatu, an endemic area in São Paulo State. The scan-test SaTScan v7.0.3 was set to find clusters for the maximum temporal period of 1 year. The temporal test indicated a significant cluster in 1985 (P<0.005). This cluster comprised 10 cases, although 2.19 were expected for this year in this area. Age and clinical presentation of these cases were typical of AF paracccidioidomycosis. The space-time test confirmed the temporal cluster in 1985 and showed the localities where the risk was higher in that year. The cluster suggests that some particularities took place in the antecedent years in those localities. Analysis of climate variables showed that soil water storage was atypically high in 1982/83 ( approximately 2.11/2.5 SD above mean), and the absolute air humidity in 1984, the year preceding the cluster, was much higher than normal ( approximately 1.6 SD above mean), conditions that may have favored, respectively, antecedent fungal growth in the soil and conidia liberation in 1984, the probable year of exposure. These climatic anomalies in this area was due to the 1982/83 El Niño event, the strongest in the last 50 years.
We describe the first cluster of AF paracoccidioidomycosis, which was potentially linked to a climatic anomaly caused by the 1982/83 El Niño Southern Oscillation. This finding is important because it may help to clarify the conditions that favor Paracoccidioides brasiliensis survival and growth in the environment and that enhance human exposure, thus allowing the development of preventive measures.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>20361032</pmid><doi>10.1371/journal.pntd.0000643</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Brazil - epidemiology Child Child, Preschool Climate Climate change Cluster Analysis Disease Disease prevention Ecology/Environmental Microbiology El Nino Environmental factors Female Fungal infections Humans Male Moisture content Paracoccidioides - isolation & purification Paracoccidioidomycosis - epidemiology Precipitation Retrospective Studies Soil water Southern Oscillation Studies Tropical diseases Water storage Young Adult |
| title | First description of a cluster of acute/subacute paracoccidioidomycosis cases and its association with a climatic anomaly |
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