The first human epitope map of the alphaviral E1 and E2 proteins reveals a new E2 epitope with significant virus neutralizing activity

Venezuelan equine encephalitis virus (VEEV) is responsible for VEE epidemics that occur in South and Central America and the U.S. The VEEV envelope contains two glycoproteins E1 (mediates cell membrane fusion) and E2 (binds receptor and elicits virus neutralizing antibodies). Previously we construct...

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Veröffentlicht in:	PLoS neglected tropical diseases 2010-07, Vol.4 (7), p.e739
Hauptverfasser:	Hunt, Ann R, Frederickson, Shana, Maruyama, Toshiaki, Roehrig, John T, Blair, Carol D
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Animals Antibodies, Neutralizing - immunology Antibodies, Neutralizing - therapeutic use Antibodies, Viral - immunology Antibodies, Viral - therapeutic use Binding sites Bone marrow Disease Models, Animal Encephalitis Virus, Venezuelan Equine - immunology Encephalomyelitis, Venezuelan Equine - drug therapy Encephalomyelitis, Venezuelan Equine - prevention & control Epitope Mapping Epitopes - immunology Glycoproteins Humans Immune response Immunology/Immune Response Immunology/Immunity to Infections Immunotherapy Light Mice Microbiology/Immunity to Infections Molecular Sequence Data Mortality Mutagenesis Neurological Disorders/Infectious Diseases of the Nervous System Neutralization Neutralization Tests Peptide Library Prophylaxis Proteins Sequence Analysis, DNA Tropical diseases Viral Envelope Proteins - immunology Virology/Emerging Viral Diseases Virology/Host Antiviral Responses
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