Chloroquine and its derivatives exacerbate B19V-associated anemia by promoting viral replication

An unexpectedly high seroprevalence and pathogenic potential of human parvovirus B19 (B19V) have been observed in certain malaria-endemic countries in parallel with local use of chloroquine (CQ) as first-line treatment for malaria. The aims of this study were to assess the effect of CQ and other com...

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Veröffentlicht in:	PLoS neglected tropical diseases 2010-04, Vol.4 (4), p.e669
Hauptverfasser:	Bönsch, Claudia, Kempf, Christoph, Mueller, Ivo, Manning, Laurens, Laman, Moses, Davis, Timothy M E, Ros, Carlos
Format:	Artikel
Sprache:	eng
Schlagworte:	Anemia Animals Antimalarials - adverse effects Antiparasitic agents Case-Control Studies Cell Line Child Child, Preschool Chloroquine - adverse effects Chloroquine - pharmacology Deoxyribonucleic acid DNA DNA, Viral - biosynthesis Drugs Epstein-Barr virus Erythema Female Hematology/Anemias Hemoglobin Humans Hypotheses Infant Infections Infectious Diseases/Epidemiology and Control of Infectious Diseases Infectious Diseases/Protozoal Infections Infectious Diseases/Viral Infections Intercellular Signaling Peptides and Proteins - pharmacology Malaria Male Medical research Metabolites Microbiology/Medical Microbiology Microbiology/Parasitology Papua New Guinea Parvoviridae Infections - virology Parvovirus B19, Human - drug effects Parvovirus B19, Human - growth & development Public Health and Epidemiology/Infectious Diseases Public Health and Epidemiology/Preventive Medicine RNA, Viral - biosynthesis Serology Tropical diseases Vector-borne diseases Virology Virus Replication - drug effects
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