Tribendimidine and albendazole for treating soil-transmitted helminths, Strongyloides stercoralis and Taenia spp.: open-label randomized trial
Tribendimidine is an anthelminthic drug with a broad spectrum of activity. In 2004 the drug was approved by Chinese authorities for human use. The efficacy of tribendimidine against soil-transmitted helminths (Ascaris lumbricoides, hookworm, and Trichuris trichiura) has been established, and new lab...
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| description | Tribendimidine is an anthelminthic drug with a broad spectrum of activity. In 2004 the drug was approved by Chinese authorities for human use. The efficacy of tribendimidine against soil-transmitted helminths (Ascaris lumbricoides, hookworm, and Trichuris trichiura) has been established, and new laboratory investigations point to activity against cestodes and Strongyloides ratti.
In an open-label randomized trial, the safety and efficacy of a single oral dose of albendazole or tribendimidine (both drugs administered at 200 mg for 5- to 14-year-old children, and 400 mg for individuals > or = 15 years) against soil-transmitted helminths, Strongyloides stercoralis, and Taenia spp. were assessed in a village in Yunnan province, People's Republic of China. The analysis was on a per-protocol basis and the trial is registered with controlled-trials.com (number ISRCTN01779485). Both albendazole and tribendimidine were highly efficacious against A. lumbricoides and, moderately, against hookworm. The efficacy against T. trichiura was low. Among 57 individuals who received tribendimidine, the prevalence of S. stercoralis was reduced from 19.3% to 8.8% (observed cure rate 54.5%, p = 0.107), and that of Taenia spp. from 26.3% to 8.8% (observed cure rate 66.7%, p = 0.014). Similar prevalence reductions were noted among the 66 albendazole recipients. Taking into account "new" infections discovered at treatment evaluation, which were most likely missed pre-treatment due to the lack of sensitivity of available diagnostic approaches, the difference between the drug-specific net Taenia spp. cure rates was highly significant in favor of tribendimidine (p = 0.001). No significant adverse events of either drug were observed.
Our results suggest that single-dose oral tribendimidine can be employed in settings with extensive intestinal polyparasitism, and its efficacy against A. lumbricoides and hookworm was confirmed. The promising results obtained with tribendimidine against S. stercoralis and Taenia spp. warrant further investigations. In a next step, multiple-dose schedules should be evaluated. |
| doi_str_mv | 10.1371/journal.pntd.0000322 |
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In an open-label randomized trial, the safety and efficacy of a single oral dose of albendazole or tribendimidine (both drugs administered at 200 mg for 5- to 14-year-old children, and 400 mg for individuals > or = 15 years) against soil-transmitted helminths, Strongyloides stercoralis, and Taenia spp. were assessed in a village in Yunnan province, People's Republic of China. The analysis was on a per-protocol basis and the trial is registered with controlled-trials.com (number ISRCTN01779485). Both albendazole and tribendimidine were highly efficacious against A. lumbricoides and, moderately, against hookworm. The efficacy against T. trichiura was low. Among 57 individuals who received tribendimidine, the prevalence of S. stercoralis was reduced from 19.3% to 8.8% (observed cure rate 54.5%, p = 0.107), and that of Taenia spp. from 26.3% to 8.8% (observed cure rate 66.7%, p = 0.014). Similar prevalence reductions were noted among the 66 albendazole recipients. Taking into account "new" infections discovered at treatment evaluation, which were most likely missed pre-treatment due to the lack of sensitivity of available diagnostic approaches, the difference between the drug-specific net Taenia spp. cure rates was highly significant in favor of tribendimidine (p = 0.001). No significant adverse events of either drug were observed.
Our results suggest that single-dose oral tribendimidine can be employed in settings with extensive intestinal polyparasitism, and its efficacy against A. lumbricoides and hookworm was confirmed. The promising results obtained with tribendimidine against S. stercoralis and Taenia spp. warrant further investigations. In a next step, multiple-dose schedules should be evaluated.</description><identifier>ISSN: 1935-2735</identifier><identifier>ISSN: 1935-2727</identifier><identifier>EISSN: 1935-2735</identifier><identifier>DOI: 10.1371/journal.pntd.0000322</identifier><identifier>PMID: 18923706</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Administration, Oral ; Adolescent ; Albendazole - administration & dosage ; Animals ; Anthelmintics - administration & dosage ; Child ; Child, Preschool ; China ; Drug dosages ; Drug therapy ; Humans ; Infections ; Infectious Diseases/Epidemiology and Control of Infectious Diseases ; Infectious Diseases/Helminth Infections ; Infectious Diseases/Neglected Tropical Diseases ; Male ; Parasites ; Parasitic diseases ; Phenylenediamines - administration & dosage ; Public Health and Epidemiology ; Public Health and Epidemiology/Infectious Diseases ; Soil - parasitology ; Strongyloides stercoralis - drug effects ; Strongyloidiasis - drug therapy ; Strongyloidiasis - parasitology ; Taenia - drug effects ; Taeniasis - drug therapy ; Taeniasis - parasitology ; Treatment Outcome ; Tropical diseases</subject><ispartof>PLoS neglected tropical diseases, 2008-10, Vol.2 (10), p.e322-e322</ispartof><rights>2008 Steinmann et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Steinmann P, Zhou X-N, Du Z-W, Jiang J-Y, Xiao S-H, et al. (2008) Tribendimidine and Albendazole for Treating Soil-Transmitted Helminths, Strongyloides stercoralis and Taenia spp.: Open-Label Randomized Trial. PLoS Negl Trop Dis 2(10): e322. doi:10.1371/journal.pntd.0000322</rights><rights>Steinmann et al. 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c525t-889634c080da5895138b6f8d0b7a625b4a1e4b5a8bfaebaa6eb265ee9621cf523</citedby><cites>FETCH-LOGICAL-c525t-889634c080da5895138b6f8d0b7a625b4a1e4b5a8bfaebaa6eb265ee9621cf523</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2561005/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2561005/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18923706$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Sinnis, Photini</contributor><creatorcontrib>Steinmann, Peter</creatorcontrib><creatorcontrib>Zhou, Xiao-Nong</creatorcontrib><creatorcontrib>Du, Zun-Wei</creatorcontrib><creatorcontrib>Jiang, Jin-Yong</creatorcontrib><creatorcontrib>Xiao, Shu-Hua</creatorcontrib><creatorcontrib>Wu, Zhong-Xing</creatorcontrib><creatorcontrib>Zhou, Hui</creatorcontrib><creatorcontrib>Utzinger, Jürg</creatorcontrib><title>Tribendimidine and albendazole for treating soil-transmitted helminths, Strongyloides stercoralis and Taenia spp.: open-label randomized trial</title><title>PLoS neglected tropical diseases</title><addtitle>PLoS Negl Trop Dis</addtitle><description>Tribendimidine is an anthelminthic drug with a broad spectrum of activity. In 2004 the drug was approved by Chinese authorities for human use. The efficacy of tribendimidine against soil-transmitted helminths (Ascaris lumbricoides, hookworm, and Trichuris trichiura) has been established, and new laboratory investigations point to activity against cestodes and Strongyloides ratti.
In an open-label randomized trial, the safety and efficacy of a single oral dose of albendazole or tribendimidine (both drugs administered at 200 mg for 5- to 14-year-old children, and 400 mg for individuals > or = 15 years) against soil-transmitted helminths, Strongyloides stercoralis, and Taenia spp. were assessed in a village in Yunnan province, People's Republic of China. The analysis was on a per-protocol basis and the trial is registered with controlled-trials.com (number ISRCTN01779485). Both albendazole and tribendimidine were highly efficacious against A. lumbricoides and, moderately, against hookworm. The efficacy against T. trichiura was low. Among 57 individuals who received tribendimidine, the prevalence of S. stercoralis was reduced from 19.3% to 8.8% (observed cure rate 54.5%, p = 0.107), and that of Taenia spp. from 26.3% to 8.8% (observed cure rate 66.7%, p = 0.014). Similar prevalence reductions were noted among the 66 albendazole recipients. Taking into account "new" infections discovered at treatment evaluation, which were most likely missed pre-treatment due to the lack of sensitivity of available diagnostic approaches, the difference between the drug-specific net Taenia spp. cure rates was highly significant in favor of tribendimidine (p = 0.001). No significant adverse events of either drug were observed.
Our results suggest that single-dose oral tribendimidine can be employed in settings with extensive intestinal polyparasitism, and its efficacy against A. lumbricoides and hookworm was confirmed. The promising results obtained with tribendimidine against S. stercoralis and Taenia spp. warrant further investigations. In a next step, multiple-dose schedules should be evaluated.</description><subject>Administration, Oral</subject><subject>Adolescent</subject><subject>Albendazole - administration & dosage</subject><subject>Animals</subject><subject>Anthelmintics - administration & dosage</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>China</subject><subject>Drug dosages</subject><subject>Drug therapy</subject><subject>Humans</subject><subject>Infections</subject><subject>Infectious Diseases/Epidemiology and Control of Infectious Diseases</subject><subject>Infectious Diseases/Helminth Infections</subject><subject>Infectious Diseases/Neglected Tropical Diseases</subject><subject>Male</subject><subject>Parasites</subject><subject>Parasitic diseases</subject><subject>Phenylenediamines - administration & dosage</subject><subject>Public Health and Epidemiology</subject><subject>Public Health and Epidemiology/Infectious Diseases</subject><subject>Soil - parasitology</subject><subject>Strongyloides stercoralis - drug effects</subject><subject>Strongyloidiasis - drug therapy</subject><subject>Strongyloidiasis - parasitology</subject><subject>Taenia - drug effects</subject><subject>Taeniasis - drug therapy</subject><subject>Taeniasis - parasitology</subject><subject>Treatment Outcome</subject><subject>Tropical diseases</subject><issn>1935-2735</issn><issn>1935-2727</issn><issn>1935-2735</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>DOA</sourceid><recordid>eNptks9u1DAQxiMEoqXwBggiceBCltiOHacHJFTxp1IlDixnaxJPdr1y7GB7kdqH4JnxdgO0iLnYGn_zs8fzFcVzUq8Ia8nbnd8HB3Y1u6RXdQ5G6YPilHSMV7Rl_OGd_UnxJMZdXfOOS_K4OCGyo6ytxWnxcx1Mj06byWjjsASnS7CHDNx4i-XoQ5kCQjJuU0ZvbJUCuDiZlFCXW7STcWkb35RfU_Buc2290RjLmDAMPoA18Ra5BnQGyjjPq_PSz-gqCz3aMrO0n8xNZqVgwD4tHo1gIz5b1rPi28cP64vP1dWXT5cX76-qgVOeKik7wZqhlrUGLjtOmOzFKHXdtyAo7xsg2PQcZD8C9gACeyo4YicoGUZO2Vnx8sidrY9q-cqoCJWy7iThIisujwrtYafmYCYI18qDUbcJHzYKQjKDRdVTFJ2AhqGWzSBqkKKmfQ7WghzYmFnvltv2_YR6QJc_0d6D3j9xZqs2_oeiXJA8tQx4vQCC_77HmNRk4oDWgkO_j6pleZoNYzIrX_2j_H9zzVE1BB9jwPHPW0itDu76XaUO7lKLu3LZi7t9_C1a7MR-AU4z0gM</recordid><startdate>20081001</startdate><enddate>20081001</enddate><creator>Steinmann, Peter</creator><creator>Zhou, Xiao-Nong</creator><creator>Du, Zun-Wei</creator><creator>Jiang, Jin-Yong</creator><creator>Xiao, Shu-Hua</creator><creator>Wu, Zhong-Xing</creator><creator>Zhou, Hui</creator><creator>Utzinger, Jürg</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7SS</scope><scope>7T2</scope><scope>7T7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>F1W</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>H95</scope><scope>H97</scope><scope>K9.</scope><scope>L.G</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20081001</creationdate><title>Tribendimidine and albendazole for treating soil-transmitted helminths, Strongyloides stercoralis and Taenia spp.: open-label randomized trial</title><author>Steinmann, Peter ; Zhou, Xiao-Nong ; Du, Zun-Wei ; Jiang, Jin-Yong ; Xiao, Shu-Hua ; Wu, Zhong-Xing ; Zhou, Hui ; Utzinger, Jürg</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c525t-889634c080da5895138b6f8d0b7a625b4a1e4b5a8bfaebaa6eb265ee9621cf523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Administration, Oral</topic><topic>Adolescent</topic><topic>Albendazole - administration & dosage</topic><topic>Animals</topic><topic>Anthelmintics - administration & dosage</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>China</topic><topic>Drug dosages</topic><topic>Drug therapy</topic><topic>Humans</topic><topic>Infections</topic><topic>Infectious Diseases/Epidemiology and Control of Infectious Diseases</topic><topic>Infectious Diseases/Helminth Infections</topic><topic>Infectious Diseases/Neglected Tropical Diseases</topic><topic>Male</topic><topic>Parasites</topic><topic>Parasitic diseases</topic><topic>Phenylenediamines - administration & dosage</topic><topic>Public Health and Epidemiology</topic><topic>Public Health and Epidemiology/Infectious Diseases</topic><topic>Soil - parasitology</topic><topic>Strongyloides stercoralis - drug effects</topic><topic>Strongyloidiasis - drug therapy</topic><topic>Strongyloidiasis - parasitology</topic><topic>Taenia - drug effects</topic><topic>Taeniasis - drug therapy</topic><topic>Taeniasis - parasitology</topic><topic>Treatment Outcome</topic><topic>Tropical diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Steinmann, Peter</creatorcontrib><creatorcontrib>Zhou, Xiao-Nong</creatorcontrib><creatorcontrib>Du, Zun-Wei</creatorcontrib><creatorcontrib>Jiang, Jin-Yong</creatorcontrib><creatorcontrib>Xiao, Shu-Hua</creatorcontrib><creatorcontrib>Wu, Zhong-Xing</creatorcontrib><creatorcontrib>Zhou, Hui</creatorcontrib><creatorcontrib>Utzinger, Jürg</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PLoS neglected tropical diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Steinmann, Peter</au><au>Zhou, Xiao-Nong</au><au>Du, Zun-Wei</au><au>Jiang, Jin-Yong</au><au>Xiao, Shu-Hua</au><au>Wu, Zhong-Xing</au><au>Zhou, Hui</au><au>Utzinger, Jürg</au><au>Sinnis, Photini</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tribendimidine and albendazole for treating soil-transmitted helminths, Strongyloides stercoralis and Taenia spp.: open-label randomized trial</atitle><jtitle>PLoS neglected tropical diseases</jtitle><addtitle>PLoS Negl Trop Dis</addtitle><date>2008-10-01</date><risdate>2008</risdate><volume>2</volume><issue>10</issue><spage>e322</spage><epage>e322</epage><pages>e322-e322</pages><issn>1935-2735</issn><issn>1935-2727</issn><eissn>1935-2735</eissn><abstract>Tribendimidine is an anthelminthic drug with a broad spectrum of activity. In 2004 the drug was approved by Chinese authorities for human use. The efficacy of tribendimidine against soil-transmitted helminths (Ascaris lumbricoides, hookworm, and Trichuris trichiura) has been established, and new laboratory investigations point to activity against cestodes and Strongyloides ratti.
In an open-label randomized trial, the safety and efficacy of a single oral dose of albendazole or tribendimidine (both drugs administered at 200 mg for 5- to 14-year-old children, and 400 mg for individuals > or = 15 years) against soil-transmitted helminths, Strongyloides stercoralis, and Taenia spp. were assessed in a village in Yunnan province, People's Republic of China. The analysis was on a per-protocol basis and the trial is registered with controlled-trials.com (number ISRCTN01779485). Both albendazole and tribendimidine were highly efficacious against A. lumbricoides and, moderately, against hookworm. The efficacy against T. trichiura was low. Among 57 individuals who received tribendimidine, the prevalence of S. stercoralis was reduced from 19.3% to 8.8% (observed cure rate 54.5%, p = 0.107), and that of Taenia spp. from 26.3% to 8.8% (observed cure rate 66.7%, p = 0.014). Similar prevalence reductions were noted among the 66 albendazole recipients. Taking into account "new" infections discovered at treatment evaluation, which were most likely missed pre-treatment due to the lack of sensitivity of available diagnostic approaches, the difference between the drug-specific net Taenia spp. cure rates was highly significant in favor of tribendimidine (p = 0.001). No significant adverse events of either drug were observed.
Our results suggest that single-dose oral tribendimidine can be employed in settings with extensive intestinal polyparasitism, and its efficacy against A. lumbricoides and hookworm was confirmed. The promising results obtained with tribendimidine against S. stercoralis and Taenia spp. warrant further investigations. In a next step, multiple-dose schedules should be evaluated.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>18923706</pmid><doi>10.1371/journal.pntd.0000322</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1935-2735 |
| ispartof | PLoS neglected tropical diseases, 2008-10, Vol.2 (10), p.e322-e322 |
| issn | 1935-2735 1935-2727 1935-2735 |
| language | eng |
| recordid | cdi_plos_journals_1288098156 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; PubMed Central Open Access; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Administration, Oral Adolescent Albendazole - administration & dosage Animals Anthelmintics - administration & dosage Child Child, Preschool China Drug dosages Drug therapy Humans Infections Infectious Diseases/Epidemiology and Control of Infectious Diseases Infectious Diseases/Helminth Infections Infectious Diseases/Neglected Tropical Diseases Male Parasites Parasitic diseases Phenylenediamines - administration & dosage Public Health and Epidemiology Public Health and Epidemiology/Infectious Diseases Soil - parasitology Strongyloides stercoralis - drug effects Strongyloidiasis - drug therapy Strongyloidiasis - parasitology Taenia - drug effects Taeniasis - drug therapy Taeniasis - parasitology Treatment Outcome Tropical diseases |
| title | Tribendimidine and albendazole for treating soil-transmitted helminths, Strongyloides stercoralis and Taenia spp.: open-label randomized trial |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-22T06%3A30%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Tribendimidine%20and%20albendazole%20for%20treating%20soil-transmitted%20helminths,%20Strongyloides%20stercoralis%20and%20Taenia%20spp.:%20open-label%20randomized%20trial&rft.jtitle=PLoS%20neglected%20tropical%20diseases&rft.au=Steinmann,%20Peter&rft.date=2008-10-01&rft.volume=2&rft.issue=10&rft.spage=e322&rft.epage=e322&rft.pages=e322-e322&rft.issn=1935-2735&rft.eissn=1935-2735&rft_id=info:doi/10.1371/journal.pntd.0000322&rft_dat=%3Cproquest_plos_%3E733704338%3C/proquest_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1288098156&rft_id=info:pmid/18923706&rft_doaj_id=oai_doaj_org_article_b2e696a43ed84c60a8602bbbb37a8c3f&rfr_iscdi=true |