Toll-like receptor 2 impairs host defense in gram-negative sepsis caused by Burkholderia pseudomallei (Melioidosis)

Toll-like receptors (TLRs) are essential in host defense against pathogens by virtue of their capacity to detect microbes and initiate the immune response. TLR2 is seen as the most important receptor for gram-positive bacteria, while TLR4 is regarded as the gram-negative TLR. Melioidosis is a severe...

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Veröffentlicht in:	PLoS medicine 2007-07, Vol.4 (7), p.e248-e248
Hauptverfasser:	Wiersinga, W Joost, Wieland, Catharina W, Dessing, Mark C, Chantratita, Narisara, Cheng, Allen C, Limmathurotsakul, Direk, Chierakul, Wirongrong, Leendertse, Masja, Florquin, Sandrine, de Vos, Alex F, White, Nicholas, Dondorp, Arjen M, Day, Nicholas P, Peacock, Sharon J, van der Poll, Tom
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Animals Bacteremia - immunology Bacteremia - metabolism Burkholderia pseudomallei Care and treatment Causes of Cell Line Cells, Cultured Cytokines - blood Cytokines - metabolism Enzyme-Linked Immunosorbent Assay Female Gram-negative bacteria Granulocytes - immunology Granulocytes - metabolism Granulocytes - microbiology Health aspects Humans Immune system Immunology Immunology and allergy Infections Infectious Diseases Lipopolysaccharide Receptors - metabolism Macrophages, Alveolar - immunology Macrophages, Alveolar - metabolism Macrophages, Alveolar - microbiology Male Medicine in Developing Countries Melioidosis - immunology Melioidosis - metabolism Melioidosis - microbiology Mice Mice, Inbred C57BL Mice, Knockout Middle Aged Monocytes - immunology Monocytes - metabolism Monocytes - microbiology Mortality Physiological aspects Prevention Pseudomonas infections Receptor antibodies Rodents Studies Toll-Like Receptor 2 - genetics Toll-Like Receptor 2 - metabolism Toll-Like Receptor 4 - genetics Toll-Like Receptor 4 - metabolism
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