Homocysteine and coronary heart disease: meta-analysis of MTHFR case-control studies, avoiding publication bias

Moderately elevated blood levels of homocysteine are weakly correlated with coronary heart disease (CHD) risk, but causality remains uncertain. When folate levels are low, the TT genotype of the common C677T polymorphism (rs1801133) of the methylene tetrahydrofolate reductase gene (MTHFR) appreciabl...

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Veröffentlicht in:	PLoS medicine 2012-02, Vol.9 (2), p.e1001177-e1001177
Hauptverfasser:	Clarke, Robert, Bennett, Derrick A, Parish, Sarah, Verhoef, Petra, Dötsch-Klerk, Mariska, Lathrop, Mark, Xu, Peng, Nordestgaard, Børge G, Holm, Hilma, Hopewell, Jemma C, Saleheen, Danish, Tanaka, Toshihiro, Anand, Sonia S, Chambers, John C, Kleber, Marcus E, Ouwehand, Willem H, Yamada, Yoshiji, Elbers, Clara, Peters, Bas, Stewart, Alexandre F R, Reilly, Muredach M, Thorand, Barbara, Yusuf, Salim, Engert, James C, Assimes, Themistocles L, Kooner, Jaspal, Danesh, John, Watkins, Hugh, Samani, Nilesh J, Collins, Rory, Peto, Richard
Format:	Artikel
Sprache:	eng
Schlagworte:	Bias Cardiovascular disease Clinical trials Coronary Disease - blood Coronary Disease - epidemiology Coronary Disease - genetics Coronary heart disease Development and progression Folic Acid - blood Genes Genomes Genotype Health aspects Heart Homocysteine Homocysteine - blood Humans Medicine Meta-analysis Methylenetetrahydrofolate Reductase (NADPH2) - genetics Physiological aspects Polymorphism, Genetic Risk Factors Studies Vitamin B
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