Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children

The FTO gene harbors the strongest known susceptibility locus for obesity. While many individual studies have suggested that physical activity (PA) may attenuate the effect of FTO on obesity risk, other studies have not been able to confirm this interaction. To confirm or refute unambiguously whethe...

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Veröffentlicht in:	PLoS medicine 2011-11, Vol.8 (11), p.e1001116-e1001116
Hauptverfasser:	Kilpeläinen, Tuomas O, Qi, Lu, Brage, Soren, Sharp, Stephen J, Sonestedt, Emily, Demerath, Ellen, Ahmad, Tariq, Mora, Samia, Kaakinen, Marika, Sandholt, Camilla Helene, Holzapfel, Christina, Autenrieth, Christine S, Hyppönen, Elina, Cauchi, Stéphane, He, Meian, Kutalik, Zoltan, Kumari, Meena, Stančáková, Alena, Meidtner, Karina, Balkau, Beverley, Tan, Jonathan T, Mangino, Massimo, Timpson, Nicholas J, Song, Yiqing, Zillikens, M Carola, Jablonski, Kathleen A, Garcia, Melissa E, Johansson, Stefan, Bragg-Gresham, Jennifer L, Wu, Ying, van Vliet-Ostaptchouk, Jana V, Onland-Moret, N Charlotte, Zimmermann, Esther, Rivera, Natalia V, Tanaka, Toshiko, Stringham, Heather M, Silbernagel, Günther, Kanoni, Stavroula, Feitosa, Mary F, Snitker, Soren, Ruiz, Jonatan R, Metter, Jeffery, Larrad, Maria Teresa Martinez, Atalay, Mustafa, Hakanen, Maarit, Amin, Najaf, Cavalcanti-Proença, Christine, Grøntved, Anders, Hallmans, Göran, Jansson, John-Olov, Kuusisto, Johanna, Kähönen, Mika, Lutsey, Pamela L, Nolan, John J, Palla, Luigi, Pedersen, Oluf, Pérusse, Louis, Renström, Frida, Scott, Robert A, Shungin, Dmitry, Sovio, Ulla, Tammelin, Tuija H, Rönnemaa, Tapani, Lakka, Timo A, Uusitupa, Matti, Rios, Manuel Serrano, Ferrucci, Luigi, Bouchard, Claude, Meirhaeghe, Aline, Fu, Mao, Walker, Mark, Borecki, Ingrid B, Dedoussis, George V, Fritsche, Andreas, Ohlsson, Claes, Boehnke, Michael, Bandinelli, Stefania, van Duijn, Cornelia M, Ebrahim, Shah, Lawlor, Debbie A, Gudnason, Vilmundur, Harris, Tamara B, Sørensen, Thorkild I A, Mohlke, Karen L, Hofman, Albert, Uitterlinden, André G, Tuomilehto, Jaakko, Lehtimäki, Terho, Raitakari, Olli, Isomaa, Bo, Njølstad, Pål R, Florez, Jose C, Liu, Simin, Ness, Andy, Spector, Timothy D, Tai, E Shyong, Froguel, Philippe, Boeing, Heiner, Laakso, Markku, Marmot, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue Adipose Tissue - metabolism Adolescent Adult Aged Alpha-Ketoglutarate-Dependent Dioxygenase FTO Biology Child Clinical Medicine Disease susceptibility Endocrinology and Diabetes Endokrinologi och diabetes Exercise Female Genes Genetic Predisposition to Disease Genotype Health aspects Humans Klinisk medicin Life Sciences Male Medical and Health Sciences Medicin och hälsovetenskap Medicine Meta-analysis Motor Activity Obesity Obesity - genetics Obesity - metabolism Obesity - physiopathology Polymorphism, Single Nucleotide Prevention Proteins Proteins - genetics Risk Factors Santé publique et épidémiologie Social and Behavioral Sciences Studies Teenagers
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