Effect of pneumococcal conjugate vaccination on serotype-specific carriage and invasive disease in England: a cross-sectional study

We investigated the effect of the 7-valent pneumococcal conjugate vaccine (PCV7) programme in England on serotype-specific carriage and invasive disease to help understand its role in serotype replacement and predict the impact of higher valency vaccines. Nasopharyngeal swabs were taken from childre...

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Veröffentlicht in:	PLoS medicine 2011-04, Vol.8 (4), p.e1001017-e1001017
Hauptverfasser:	Flasche, Stefan, Van Hoek, Albert Jan, Sheasby, Elizabeth, Waight, Pauline, Andrews, Nick, Sheppard, Carmen, George, Robert, Miller, Elizabeth
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Bacteria Bacterial Diseases Bacterial pneumonia Bacterial vaccines Carrier State - immunology Carrier State - microbiology Child Child, Preschool Communicable Diseases - epidemiology Communicable Diseases - immunology Communicable Diseases - microbiology Confidence intervals Cross-Sectional Studies Disease England - epidemiology Epidemiology Female Health aspects Humans Immunization Programs Infectious Disease Epidemiology Infectious Diseases Male Medicine Nasopharynx - immunology Nasopharynx - microbiology Odds Ratio Pneumococcal Infections - epidemiology Pneumococcal Infections - immunology Pneumococcal Infections - microbiology Pneumococcal Vaccines - immunology Pneumococcus Pneumonia Population Prevalence Prevention Serotyping Streptococcus infections Streptococcus pneumoniae Streptococcus pneumoniae - classification Streptococcus pneumoniae - immunology Studies Vaccination - methods Vaccines Vaccines, Conjugate - immunology Vaccines, Conjugate - microbiology Young Adult
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Zusammenfassung:	We investigated the effect of the 7-valent pneumococcal conjugate vaccine (PCV7) programme in England on serotype-specific carriage and invasive disease to help understand its role in serotype replacement and predict the impact of higher valency vaccines. Nasopharyngeal swabs were taken from children
ISSN:	1549-1676 1549-1277 1549-1676
DOI:	10.1371/journal.pmed.1001017