Pneumococcal serotypes and mortality following invasive pneumococcal disease: a population-based cohort study
Pneumococcal disease is a leading cause of morbidity and mortality worldwide. The aim of this study was to investigate the association between specific pneumococcal serotypes and mortality from invasive pneumococcal disease (IPD). In a nationwide population-based cohort study of IPD in Denmark durin...
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| Veröffentlicht in: | PLoS medicine 2009-05, Vol.6 (5), p.e1000081-e1000081 |
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| creator | Harboe, Zitta B Thomsen, Reimar W Riis, Anders Valentiner-Branth, Palle Christensen, Jens Jørgen Lambertsen, Lotte Krogfelt, Karen A Konradsen, Helle B Benfield, Thomas L |
| description | Pneumococcal disease is a leading cause of morbidity and mortality worldwide. The aim of this study was to investigate the association between specific pneumococcal serotypes and mortality from invasive pneumococcal disease (IPD).
In a nationwide population-based cohort study of IPD in Denmark during 1977-2007, 30-d mortality associated with pneumococcal serotypes was examined by multivariate logistic regression analysis after controlling for potential confounders. A total of 18,858 IPD patients were included. Overall 30-d mortality was 18%, and 3% in children younger than age 5 y. Age, male sex, meningitis, high comorbidity level, alcoholism, and early decade of diagnosis were significantly associated with mortality. Among individuals aged 5 y and older, serotypes 31, 11A, 35F, 17F, 3, 16F, 19F, 15B, and 10A were associated with highly increased mortality as compared with serotype 1 (all: adjusted odds ratio >or=3, p |
| doi_str_mv | 10.1371/journal.pmed.1000081 |
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In a nationwide population-based cohort study of IPD in Denmark during 1977-2007, 30-d mortality associated with pneumococcal serotypes was examined by multivariate logistic regression analysis after controlling for potential confounders. A total of 18,858 IPD patients were included. Overall 30-d mortality was 18%, and 3% in children younger than age 5 y. Age, male sex, meningitis, high comorbidity level, alcoholism, and early decade of diagnosis were significantly associated with mortality. Among individuals aged 5 y and older, serotypes 31, 11A, 35F, 17F, 3, 16F, 19F, 15B, and 10A were associated with highly increased mortality as compared with serotype 1 (all: adjusted odds ratio >or=3, p<0.001). In children younger than 5 y, associations between serotypes and mortality were different than in adults but statistical precision was limited because of low overall childhood-related mortality.
Specific pneumococcal serotypes strongly and independently affect IPD associated mortality.</description><identifier>ISSN: 1549-1676</identifier><identifier>ISSN: 1549-1277</identifier><identifier>EISSN: 1549-1676</identifier><identifier>DOI: 10.1371/journal.pmed.1000081</identifier><identifier>PMID: 19468297</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adolescent ; Adult ; Aged ; Child ; Child, Preschool ; Cohort Studies ; Denmark - epidemiology ; Female ; Humans ; Infectious Diseases/Bacterial Infections ; Infectious Diseases/Epidemiology and Control of Infectious Diseases ; Infectious Diseases/Infectious Diseases of the Nervous System ; Infectious Diseases/Respiratory Infections ; Logistic Models ; Male ; Microbiology/Immunity to Infections ; Microbiology/Medical Microbiology ; Middle Aged ; Multivariate Analysis ; Pediatrics and Child Health ; Pneumococcal Infections - microbiology ; Pneumococcal Infections - mortality ; Pneumococcal Infections - prevention & control ; Pneumococcal Vaccines - immunology ; Pneumococcal Vaccines - therapeutic use ; Prevalence ; Public Health and Epidemiology ; Public Health and Epidemiology/Global Health ; Public Health and Epidemiology/Immunization ; Public Health and Epidemiology/Infectious Diseases ; Respiratory Medicine/Respiratory Infections ; Respiratory Medicine/Respiratory Pediatrics ; Serotyping ; Streptococcus pneumoniae - classification ; Streptococcus pneumoniae - isolation & purification ; Young Adult</subject><ispartof>PLoS medicine, 2009-05, Vol.6 (5), p.e1000081-e1000081</ispartof><rights>Harboe et al. 2009</rights><rights>2009 Harboe et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Harboe ZB, Thomsen RW, Riis A, Valentiner-Branth P, Christensen JJ, et al. (2009) Pneumococcal Serotypes and Mortality following Invasive Pneumococcal Disease: A Population-Based Cohort Study. PLoS Med 6(5): e1000081. doi:10.1371/journal.pmed.1000081</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c562t-62908509d4598c6335b06d0606949b7c37803325855439ac78242b80637d0f7d3</citedby><cites>FETCH-LOGICAL-c562t-62908509d4598c6335b06d0606949b7c37803325855439ac78242b80637d0f7d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680036/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680036/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19468297$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Harboe, Zitta B</creatorcontrib><creatorcontrib>Thomsen, Reimar W</creatorcontrib><creatorcontrib>Riis, Anders</creatorcontrib><creatorcontrib>Valentiner-Branth, Palle</creatorcontrib><creatorcontrib>Christensen, Jens Jørgen</creatorcontrib><creatorcontrib>Lambertsen, Lotte</creatorcontrib><creatorcontrib>Krogfelt, Karen A</creatorcontrib><creatorcontrib>Konradsen, Helle B</creatorcontrib><creatorcontrib>Benfield, Thomas L</creatorcontrib><title>Pneumococcal serotypes and mortality following invasive pneumococcal disease: a population-based cohort study</title><title>PLoS medicine</title><addtitle>PLoS Med</addtitle><description>Pneumococcal disease is a leading cause of morbidity and mortality worldwide. The aim of this study was to investigate the association between specific pneumococcal serotypes and mortality from invasive pneumococcal disease (IPD).
In a nationwide population-based cohort study of IPD in Denmark during 1977-2007, 30-d mortality associated with pneumococcal serotypes was examined by multivariate logistic regression analysis after controlling for potential confounders. A total of 18,858 IPD patients were included. Overall 30-d mortality was 18%, and 3% in children younger than age 5 y. Age, male sex, meningitis, high comorbidity level, alcoholism, and early decade of diagnosis were significantly associated with mortality. Among individuals aged 5 y and older, serotypes 31, 11A, 35F, 17F, 3, 16F, 19F, 15B, and 10A were associated with highly increased mortality as compared with serotype 1 (all: adjusted odds ratio >or=3, p<0.001). In children younger than 5 y, associations between serotypes and mortality were different than in adults but statistical precision was limited because of low overall childhood-related mortality.
Specific pneumococcal serotypes strongly and independently affect IPD associated mortality.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cohort Studies</subject><subject>Denmark - epidemiology</subject><subject>Female</subject><subject>Humans</subject><subject>Infectious Diseases/Bacterial Infections</subject><subject>Infectious Diseases/Epidemiology and Control of Infectious Diseases</subject><subject>Infectious Diseases/Infectious Diseases of the Nervous System</subject><subject>Infectious Diseases/Respiratory Infections</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Microbiology/Immunity to Infections</subject><subject>Microbiology/Medical Microbiology</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Pediatrics and Child Health</subject><subject>Pneumococcal Infections - microbiology</subject><subject>Pneumococcal Infections - mortality</subject><subject>Pneumococcal Infections - prevention & control</subject><subject>Pneumococcal Vaccines - immunology</subject><subject>Pneumococcal Vaccines - therapeutic use</subject><subject>Prevalence</subject><subject>Public Health and Epidemiology</subject><subject>Public Health and Epidemiology/Global Health</subject><subject>Public Health and Epidemiology/Immunization</subject><subject>Public Health and Epidemiology/Infectious Diseases</subject><subject>Respiratory Medicine/Respiratory Infections</subject><subject>Respiratory Medicine/Respiratory Pediatrics</subject><subject>Serotyping</subject><subject>Streptococcus pneumoniae - classification</subject><subject>Streptococcus pneumoniae - isolation & purification</subject><subject>Young Adult</subject><issn>1549-1676</issn><issn>1549-1277</issn><issn>1549-1676</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>DOA</sourceid><recordid>eNpVUsuOEzEQtBCIXQJ_gMAnbgl-PzggoRWPlVaCA5wtj-1kHXnGgz0TlL_HIQNk2we32tVVbbsAeInRBlOJ3-7zXAabNmMf_AajFgo_AteYM73GQorHF_kVeFbrHiGikUZPwRXWTCii5TXovw1h7rPLztkEayh5Oo6hQjt42Ocy2RSnI9zmlPKvOOxgHA62xkOA42WfjzXYGt5BC8c8zslOMQ_rrpU8dPm-8cA6zf74HDzZ2lTDi2VfgR-fPn6_-bK--_r59ubD3dpxQaa1aHMqjrRnXCsnKOUdEh4JJDTTnXRUKkQp4YpzRrV1UhFGOoUElR5tpacr8PrMO6ZczfJS1WCiFFKKatwQt2eEz3ZvxhJ7W44m22j-FHLZGVum6FIwkmmLmXChU5wF0mnU9AVnLXhbrHG9X9Tmrn2GC8NUbHpA-vBkiPdmlw-GCIUQFY3gzUJQ8s851Mn0sbqQkh1CnqsRkkh5GnwF2BnoSq61hO0_EYzMyRV_72pOrjCLK1rbq8sB_zctNqC_Acfztl8</recordid><startdate>20090526</startdate><enddate>20090526</enddate><creator>Harboe, Zitta B</creator><creator>Thomsen, Reimar W</creator><creator>Riis, Anders</creator><creator>Valentiner-Branth, Palle</creator><creator>Christensen, Jens Jørgen</creator><creator>Lambertsen, Lotte</creator><creator>Krogfelt, Karen A</creator><creator>Konradsen, Helle B</creator><creator>Benfield, Thomas L</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><scope>CZK</scope></search><sort><creationdate>20090526</creationdate><title>Pneumococcal serotypes and mortality following invasive pneumococcal disease: a population-based cohort study</title><author>Harboe, Zitta B ; Thomsen, Reimar W ; Riis, Anders ; Valentiner-Branth, Palle ; Christensen, Jens Jørgen ; Lambertsen, Lotte ; Krogfelt, Karen A ; Konradsen, Helle B ; Benfield, Thomas L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c562t-62908509d4598c6335b06d0606949b7c37803325855439ac78242b80637d0f7d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Cohort Studies</topic><topic>Denmark - epidemiology</topic><topic>Female</topic><topic>Humans</topic><topic>Infectious Diseases/Bacterial Infections</topic><topic>Infectious Diseases/Epidemiology and Control of Infectious Diseases</topic><topic>Infectious Diseases/Infectious Diseases of the Nervous System</topic><topic>Infectious Diseases/Respiratory Infections</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Microbiology/Immunity to Infections</topic><topic>Microbiology/Medical Microbiology</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Pediatrics and Child Health</topic><topic>Pneumococcal Infections - microbiology</topic><topic>Pneumococcal Infections - mortality</topic><topic>Pneumococcal Infections - prevention & control</topic><topic>Pneumococcal Vaccines - immunology</topic><topic>Pneumococcal Vaccines - therapeutic use</topic><topic>Prevalence</topic><topic>Public Health and Epidemiology</topic><topic>Public Health and Epidemiology/Global Health</topic><topic>Public Health and Epidemiology/Immunization</topic><topic>Public Health and Epidemiology/Infectious Diseases</topic><topic>Respiratory Medicine/Respiratory Infections</topic><topic>Respiratory Medicine/Respiratory Pediatrics</topic><topic>Serotyping</topic><topic>Streptococcus pneumoniae - classification</topic><topic>Streptococcus pneumoniae - isolation & purification</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Harboe, Zitta B</creatorcontrib><creatorcontrib>Thomsen, Reimar W</creatorcontrib><creatorcontrib>Riis, Anders</creatorcontrib><creatorcontrib>Valentiner-Branth, Palle</creatorcontrib><creatorcontrib>Christensen, Jens Jørgen</creatorcontrib><creatorcontrib>Lambertsen, Lotte</creatorcontrib><creatorcontrib>Krogfelt, Karen A</creatorcontrib><creatorcontrib>Konradsen, Helle B</creatorcontrib><creatorcontrib>Benfield, Thomas L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><collection>PLoS Medicine</collection><jtitle>PLoS medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Harboe, Zitta B</au><au>Thomsen, Reimar W</au><au>Riis, Anders</au><au>Valentiner-Branth, Palle</au><au>Christensen, Jens Jørgen</au><au>Lambertsen, Lotte</au><au>Krogfelt, Karen A</au><au>Konradsen, Helle B</au><au>Benfield, Thomas L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pneumococcal serotypes and mortality following invasive pneumococcal disease: a population-based cohort study</atitle><jtitle>PLoS medicine</jtitle><addtitle>PLoS Med</addtitle><date>2009-05-26</date><risdate>2009</risdate><volume>6</volume><issue>5</issue><spage>e1000081</spage><epage>e1000081</epage><pages>e1000081-e1000081</pages><issn>1549-1676</issn><issn>1549-1277</issn><eissn>1549-1676</eissn><abstract>Pneumococcal disease is a leading cause of morbidity and mortality worldwide. The aim of this study was to investigate the association between specific pneumococcal serotypes and mortality from invasive pneumococcal disease (IPD).
In a nationwide population-based cohort study of IPD in Denmark during 1977-2007, 30-d mortality associated with pneumococcal serotypes was examined by multivariate logistic regression analysis after controlling for potential confounders. A total of 18,858 IPD patients were included. Overall 30-d mortality was 18%, and 3% in children younger than age 5 y. Age, male sex, meningitis, high comorbidity level, alcoholism, and early decade of diagnosis were significantly associated with mortality. Among individuals aged 5 y and older, serotypes 31, 11A, 35F, 17F, 3, 16F, 19F, 15B, and 10A were associated with highly increased mortality as compared with serotype 1 (all: adjusted odds ratio >or=3, p<0.001). In children younger than 5 y, associations between serotypes and mortality were different than in adults but statistical precision was limited because of low overall childhood-related mortality.
Specific pneumococcal serotypes strongly and independently affect IPD associated mortality.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>19468297</pmid><doi>10.1371/journal.pmed.1000081</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Aged Child Child, Preschool Cohort Studies Denmark - epidemiology Female Humans Infectious Diseases/Bacterial Infections Infectious Diseases/Epidemiology and Control of Infectious Diseases Infectious Diseases/Infectious Diseases of the Nervous System Infectious Diseases/Respiratory Infections Logistic Models Male Microbiology/Immunity to Infections Microbiology/Medical Microbiology Middle Aged Multivariate Analysis Pediatrics and Child Health Pneumococcal Infections - microbiology Pneumococcal Infections - mortality Pneumococcal Infections - prevention & control Pneumococcal Vaccines - immunology Pneumococcal Vaccines - therapeutic use Prevalence Public Health and Epidemiology Public Health and Epidemiology/Global Health Public Health and Epidemiology/Immunization Public Health and Epidemiology/Infectious Diseases Respiratory Medicine/Respiratory Infections Respiratory Medicine/Respiratory Pediatrics Serotyping Streptococcus pneumoniae - classification Streptococcus pneumoniae - isolation & purification Young Adult |
| title | Pneumococcal serotypes and mortality following invasive pneumococcal disease: a population-based cohort study |
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