An erythroid differentiation signature predicts response to lenalidomide in myelodysplastic syndrome

Lenalidomide is an effective new agent for the treatment of patients with myelodysplastic syndrome (MDS), an acquired hematopoietic disorder characterized by ineffective blood cell production and a predisposition to the development of leukemia. Patients with an interstitial deletion of Chromosome 5q...

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Veröffentlicht in:	PLoS medicine 2008-02, Vol.5 (2), p.e35
Hauptverfasser:	Ebert, Benjamin L, Galili, Naomi, Tamayo, Pablo, Bosco, Jocelyn, Mak, Raymond, Pretz, Jennifer, Tanguturi, Shyam, Ladd-Acosta, Christine, Stone, Richard, Golub, Todd R, Raza, Azra
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Blood clots Bone marrow Cancer Cancer therapies Cell Differentiation - drug effects Cell Differentiation - genetics Cells, Cultured Chemotherapy Chromosome Deletion Chromosomes Chromosomes, Human, Pair 5 - drug effects Chromosomes, Human, Pair 5 - genetics Clinical Trials, Phase II as Topic - methods Colonies & territories Confidence intervals Cytokines Defects Drug dosages Erythroid Precursor Cells - drug effects Erythroid Precursor Cells - physiology Erythropoiesis - drug effects Erythropoiesis - genetics Experiments Gene expression Gene Expression Profiling - methods Genetic Markers - drug effects Genetic Markers - genetics Genetics and Genomics Hematology Hematology (including Blood Transfusion) Hematopoietic Stem Cells - drug effects Hematopoietic Stem Cells - physiology Humans Lenalidomide Leukemia Male Medical research Middle Aged Myelodysplastic Syndromes - blood Myelodysplastic Syndromes - drug therapy Myelodysplastic Syndromes - genetics Oncology Predictive Value of Tests Studies Thalidomide - analogs & derivatives Thalidomide - pharmacology Thalidomide - therapeutic use Transplants & implants
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