Statins impair antitumor effects of rituximab by inducing conformational changes of CD20

Rituximab is used in the treatment of CD20+ B cell lymphomas and other B cell lymphoproliferative disorders. Its clinical efficacy might be further improved by combinations with other drugs such as statins that inhibit cholesterol synthesis and show promising antilymphoma effects. The objective of t...

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Veröffentlicht in:	PLoS medicine 2008-03, Vol.5 (3), p.e64-e64
Hauptverfasser:	Winiarska, Magdalena, Bil, Jacek, Wilczek, Ewa, Wilczynski, Grzegorz M, Lekka, Malgorzata, Engelberts, Patrick J, Mackus, Wendy J M, Gorska, Elzbieta, Bojarski, Lukasz, Stoklosa, Tomasz, Nowis, Dominika, Kurzaj, Zuzanna, Makowski, Marcin, Glodkowska, Eliza, Issat, Tadeusz, Mrowka, Piotr, Lasek, Witold, Dabrowska-Iwanicka, Anna, Basak, Grzegorz W, Wasik, Maria, Warzocha, Krzysztof, Sinski, Maciej, Gaciong, Zbigniew, Jakobisiak, Marek, Parren, Paul W H I, Golab, Jakub
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - drug effects Antibodies, Monoclonal - metabolism Antibodies, Monoclonal - therapeutic use Antibodies, Monoclonal, Murine-Derived Antibody-Dependent Cell Cytotoxicity - drug effects Antigens, CD20 - chemistry Antigens, CD20 - drug effects Antineoplastic Agents - antagonists & inhibitors B-Lymphocytes - metabolism Cancer therapies Cell Line, Tumor Cells Chemotherapy Cholesterol Cholesterol - pharmacology Cytotoxicity Cytotoxicity, Immunologic - drug effects Drugs Hematology Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects Hypercholesterolemia - blood Hypercholesterolemia - drug therapy Immunology Immunology and Allergy Lovastatin - pharmacology Lymphocytes Lymphoma Lymphoma, B-Cell - drug therapy Medical laboratories Medical research Membrane Microdomains - drug effects Microscopy Monoclonal antibodies Oncology Pharmacology and Toxicology Plasma Protein Conformation - drug effects Researchers Rituximab Statins
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