Targeted killing of virally infected cells by radiolabeled antibodies to viral proteins

The HIV epidemic is a major threat to health in the developing and western worlds. A modality that targets and kills HIV-1-infected cells could have a major impact on the treatment of acute exposure and the elimination of persistent reservoirs of infected cells. The aim of this proof-of-principle st...

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Veröffentlicht in:	PLoS medicine 2006-11, Vol.3 (11), p.e427
Hauptverfasser:	Dadachova, Ekaterina, Patel, Mahesh C, Toussi, Sima, Apostolidis, Christos, Morgenstern, Alfred, Brechbiel, Martin W, Gorny, Miroslaw K, Zolla-Pazner, Susan, Casadevall, Arturo, Goldstein, Harris
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome AIDS Analysis Animals Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal - pharmacology Antibodies, Viral - administration & dosage Antibodies, Viral - pharmacology Biotechnology Bismuth Blood Care and treatment Cell Death Cells, Cultured Cytotoxins - administration & dosage Cytotoxins - pharmacology Dose-Response Relationship, Drug Drug dosages Drug targeting Drug therapy HIV HIV Envelope Protein gp120 - immunology HIV Envelope Protein gp41 - immunology HIV infection HIV Infection/AIDS HIV Infections - physiopathology HIV-1 HIV/AIDS Human immunodeficiency virus Humans Immunology Immunotherapy Infections Infectious Diseases Leukocytes Medical research Methods Mice Mice, SCID Microbiology Monoclonal antibodies Monocytes - virology Proteins Public domain Radioisotopes Radiotherapy Rhenium Spleen - virology T-Lymphocytes - virology Thymus Gland - transplantation Thymus Gland - virology Transplantation, Heterologous Vaccines Viral Proteins - immunology
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